ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Complex structure of electrophysiological gradients emerging during long-duration ventricular fibrillation in the canine heart.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Ventricular fibrillation dynamics reveal regional asymmetry in resilience to cardiac arrest and predict clinical outcome.Cardiovascular research · 2026Article
- Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time.Heart international · 2026Review
- Organized Structure of Ventricular Fibrillation during Prolonged Heart Perfusion in Dogs.Sovremennye tekhnologii v meditsine · 2021Article
- Optical mapping of the pig heart in situ under artificial blood circulation.Scientific reports · 2020Article
- Endocardial Activation Drives Activation Patterns During Long-Duration Ventricular Fibrillation and Defibrillation.Circulation. Arrhythmia and electrophysiology · 2017Article
- β-Adrenergic stimulation and rapid pacing mutually promote heterogeneous electrical failure and ventricular fibrillation in the globally ischemic heart.American journal of physiology. Heart and circulatory physiology · 2015Article
- Mitochondrial depolarization and asystole in the globally ischemic rabbit heart: coordinated response to interventions affecting energy balance.American journal of physiology. Heart and circulatory physiology · 2015Article
- Does the combination of hyperkalemia and KATP activation determine excitation rate gradient and electrical failure in the globally ischemic fibrillating heart?American journal of physiology. Heart and circulatory physiology · 2013Article
- Article
- Optical mapping at increased illumination intensities.Journal of biomedical optics · 2012Article
- Role of KATP channel in electrical depression and asystole during long-duration ventricular fibrillation in ex vivo canine heart.American journal of physiology. Heart and circulatory physiology · 2012Article
- Intramural optical mapping of V(m) and Ca(i)2+ during long-duration ventricular fibrillation in canine hearts.American journal of physiology. Heart and circulatory physiology · 2012Article
- Imaging electrical excitation inside the myocardial wall.Biomedical optics express · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Long-duration ventricular fibrillation (LDVF) in the globally ischemic heart is a common setting of cardiac arrest. Electrical heterogeneities during LDVF may affect outcomes of defibrillation and resuscitation. Previous studies in large mammalian hearts have investigated the role of Purkinje fibers and electrophysiological gradients between the endocardium (Endo) and epicardium (Epi). Much less is known about gradients between the right ventricle (RV) and left ventricle (LV) and within each chamber during LDVF. We studied the transmural distribution of the VF activation rate (VFR) in the RV and LV and at the junction of RV, LV, and septum (Sep) during LDVF using plunge needle electrodes in opened-chest dogs. We also used optical mapping to analyze the Epi distribution of VFR, action potential duration (APD), and diastolic interval (DI) during LDVF in the RV and LV of isolated hearts. Transmural VFR gradients developed in both the RV and LV, with a faster VFR in Endo. Concurrently, large VFR gradients developed in Epi, with the fastest VFR in the RV-Sep junction, intermediate in the RV, and slowest in the LV. Optical mapping revealed a progressively increasing VFR dispersion within both the LV and RV, with a mosaic presence of fully inexcitable areas after 4-8 min of LDVF. The transmural, interchamber, and intrachamber VFR heterogeneities were of similar magnitude. In both chambers, the inverse of VFR was highly correlated with DI, but not APD, at all time points of LDVF. We conclude that the complex VFR gradients during LDVF in the canine heart cannot be explained solely by the distribution of Purkinje fibers and are related to regional differences in the electrical depression secondary to LDVF.
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