ArticleApplied and environmental microbiology2010
Link between phosphate starvation and glycogen metabolism in Corynebacterium glutamicum, revealed by metabolomics.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Energy-translation coupling limits anaerobic yeast growth.Nature communications · 2026Article
- OftenFrontiers in microbiology · 2025Article
- Microbial synthesis of the plant natural product precursor p-coumaric acid with Corynebacterium glutamicum.Microbial cell factories · 2023Article
- Phosphate Starvation by Energy Metabolism Disturbance inMolecules (Basel, Switzerland) · 2022Article
- Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing BacteriumFrontiers in microbiology · 2019Article
- Mu-driven transposition of recombinant mini-Mu unit DNA in the Corynebacterium glutamicum chromosome.Applied microbiology and biotechnology · 2018Article
- Systems analysis of phosphate-limitation-induced lipid accumulation by the oleaginous yeastBiotechnology for biofuels · 2018Article
- System-Wide Adaptations of Desulfovibrio alaskensis G20 to Phosphate-Limited Conditions.PloS one · 2016Article
- Regulation of the pstSCAB operon in Corynebacterium glutamicum by the regulator of acetate metabolism RamB.BMC microbiology · 2015Article
- Changes in protein abundance are observed in bacterial isolates from a natural host.Frontiers in cellular and infection microbiology · 2015Article
- Trends in bacterial trehalose metabolism and significant nodes of metabolic pathway in the direction of trehalose accumulation.Microbial biotechnology · 2013Review
- Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape and glycogen metabolism.Bioscience reports · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we analyzed the influence of phosphate (P(i)) limitation on the metabolism of Corynebacterium glutamicum. Metabolite analysis by gas chromatography-time-of-flight (GC-TOF) mass spectrometry of cells cultivated in glucose minimal medium revealed a greatly increased maltose level under P(i) limitation. As maltose formation could be linked to glycogen metabolism, the cellular glycogen content was determined. Unlike in cells grown under P(i) excess, the glycogen level in P(i)-limited cells remained high in the stationary phase. Surprisingly, even acetate-grown cells, which do not form glycogen under P(i) excess, did so under P(i) limitation and also retained it in stationary phase. Expression of pgm and glgC, encoding the first two enzymes of glycogen synthesis, phosphoglucomutase and ADP-glucose pyrophosphorylase, was found to be increased 6- and 3-fold under P(i) limitation, respectively. Increased glycogen synthesis together with a decreased glycogen degradation might be responsible for the altered glycogen metabolism. Independent from these experimental results, flux balance analysis suggested that an increased carbon flux to glycogen is a solution for C. glutamicum to adapt carbon metabolism to limited P(i) concentrations.
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