Evidence map›Paper›PMID 20802035›Full record

ArticleJournal of bacteriology2010

A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407.

Lisa C Crossman, Roy R Chaudhuri, Scott A Beatson, Timothy J Wells, Mickael Desvaux, Adam F Cunningham, Nicola K Petty, Vivienne Mahon, Carl Brinkley, Jon L Hobman and 10 more

Abstract read
In one paragraph

Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed.

  1. Flagellar regulation in enterotoxigenicInfection and immunity · 2026
    Article
  2. Article
  3. Occurrence of enterotoxigenicFrontiers in environmental science · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Comparative Pathogenomics ofInfection and immunity · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Multidrug-Resistant Lineage of EnterotoxigenicFrontiers in microbiology · 2021
    Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lisa C CrossmanThe Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom.
Roy R Chaudhuri
Scott A Beatson
Timothy J Wells
Mickael Desvaux
Adam F Cunningham
Nicola K Petty
Vivienne Mahon
Carl Brinkley
Jon L Hobman
Stephen J Savarino
Susan M Turner
Mark J Pallen
Charles W Penn
Julian Parkhill
A Keith Turner
Timothy J Johnson
Nicholas R Thomson
Stephen G J Smith
Ian R Henderson

Funding

Biotechnology and Biological Sciences Research Council BB/C510075/1Medical Research Council G0801209Wellcome Trust
6 · The paper itself

Abstract

In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominant cause of E. coli-mediated diarrhea in the developing world and is responsible for a significant portion of pediatric deaths. In this study, we determined the complete genomic sequence of E. coli H10407, a prototypical strain of enterotoxigenic E. coli, which reproducibly elicits diarrhea in human volunteer studies. We performed genomic and phylogenetic comparisons with other E. coli strains, revealing that the chromosome is closely related to that of the nonpathogenic commensal strain E. coli HS and to those of the laboratory strains E. coli K-12 and C. Furthermore, these analyses demonstrated that there were no chromosomally encoded factors unique to any sequenced ETEC strains. Comparison of the E. coli H10407 plasmids with those from several ETEC strains revealed that the plasmids had a mosaic structure but that several loci were conserved among ETEC strains. This study provides a genetic context for the vast amount of experimental and epidemiological data that have been published.

Indexed as

Genome, BacterialAmino Acid SequenceChromosomes, BacterialEnterotoxigenic Escherichia coliEscherichia coli ProteinsFimbriae ProteinsGene Expression ProfilingGene Expression Regulation, BacterialMolecular Sequence DataPlasmidsEscherichia coli ProteinsFimbriae Proteins

Identifiers

PMID20802035
PMCPMC2953697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.