ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2010
Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Long-term multi-organ system abnormalities in mice exposed to antenatal and postnatal corticosteroids.Pediatric research · 2026Article
- Tissue-specific mitochondrial pathway remodeling linked to longevity in honeybee queens.PloS one · 2026Article
- A robust method for assessing mitochondrial function in healthy and diseased frozen cardiac tissue.Communications biology · 2025Article
- FNDC4 Prevents Aging-Related Cardiac Dysfunction: By Restoring AMPKα/PPARα-Dependent Mitochondrial Function.JACC. Basic to translational science · 2025Article
- Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways.Metabolites · 2022Review
- Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki).Frontiers in physiology · 2020Article
- Acute Myocardial Infarction Reduces Respiration in Rat Cardiac Fibers, despite Adipose Tissue Mesenchymal Stromal Cell Transplant.Stem cells international · 2020Article
- Article
- Isolation of mitochondrial subpopulations from skeletal muscle: Optimizing recovery and preserving integrity.Acta physiologica (Oxford, England) · 2019Article
- Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers.Scientific reports · 2017Article
- Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats.PloS one · 2017Article
- Mitochondrial Metabolism in Aging Heart.Circulation research · 2016Review
- Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy.Pathobiology of aging & age related diseases · 2016Review
- Novel Insights into Insect-Microbe Interactions-Role of Epigenomics and Small RNAs.Frontiers in plant science · 2016Review
- Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies.American journal of physiology. Heart and circulatory physiology · 2014Review
- An animal model to study human muscular diseases involving mitochondrial oxidative phosphorylation.Journal of bioenergetics and biomembranes · 2012Review
- Control of mitochondrial activity by miRNAs.Journal of cellular biochemistry · 2012Review
- Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium.PloS one · 2012Article
- Article
- The metabolic footprint of aging in mice.Scientific reports · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We measured the loss of cardiac mitochondrial function related to aging in males of three rat strains presenting with different longevity and aging phenotypes: the Fischer 344 (F344), the Brown Norway (BN), and the hybrid F344×BN. The F344 rat has a short life span and a ∼45% decrease in coupled mitochondrial oxidation in the cardiac permeabilized fibers from the old rats compared with the young rats. Citrate synthase activity in the permeabilized fibers (mitochondrial content) did not change significantly with aging. The BN live longer compared with the F344 and have a 15%-18% loss of mitochondrial respiration in the aged rats compared with the young rats. The differences are not significant. In hybrids, more resistant to aging than are the BN and the F344, mitochondrial function is preserved during aging. The difference in longevity of the different strains is correlated with mitochondrial dysfunction in the heart, suggesting the importance of mitochondria in cardiac aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.