ReviewTranslational research : the journal of laboratory and clinical medicine2010
Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche.
Review in Translational research : the journal of laboratory and clinical medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- YK-4-250, a synthetic telmisartan-tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin ATActa crystallographica. Section C, Structural chemistry · 2026Article
- A Review on Functional Foods Regulate the Gut Microbiota and Mast Cell Function in Inflammatory Bowel Disease (IBD).Probiotics and antimicrobial proteins · 2026Review
- Intestinal epithelial cells in health and disease.Tissue barriers · 2026Review
- Review
- Effect of dietary inclusion of indigenous probiotics on the growth and intestinal histomorphology of guinea pigs (Open veterinary journal · 2025Article
- Aryl Hydrocarbon Receptor (AHR) is required for repopulation of decellularized intestinal colon scaffolds.microPublication biology · 2025Article
- Navigating the Landscape of Intestinal Regeneration: A Spotlight on Quiescence Regulation and Fetal Reprogramming.International journal of stem cells · 2024Review
- Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis.Journal of inflammation research · 2024Review
- Intestinal stem cells and gut microbiota therapeutics: hype or hope?Frontiers in medicine · 2023Review
- Moving Up a NOTCH: Defining the Stem Cell Niche in the Gastric Antrum.Cellular and molecular gastroenterology and hepatology · 2022Article
- Stem cell and niche regulation in human short bowel syndrome.JCI insight · 2020Article
- Review
- Development of an Improved 3DFrontiers in bioengineering and biotechnology · 2020Article
- Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease.Frontiers in pediatrics · 2020Review
- Improving a fish intestinal barrier model by combining two rainbow trout cell lines: epithelial RTgutGC and fibroblastic RTgutF.Cytotechnology · 2019Article
- Dclk1-expressing tuft cells: critical modulators of the intestinal niche?American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells.Circulation research · 2017Review
- Monitoring Notch Signaling-Associated Activation of Stem Cell Niches within Injured Dental Pulp.Frontiers in physiology · 2017Article
- Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The intestinal epithelium contains a rapidly proliferating and perpetually differentiating epithelium. The principal functional unit of the small intestine is the crypt-villus axis. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the 4 major epithelial cell types. The study of adult gastrointestinal tract stem cells has progressed rapidly with the recent discovery of several putative stem cell markers. Substantial evidence suggests 2 populations of stem cells: long-term quiescent (reserved) and actively cycling (primed) stem cells. These cells are in adjoining locations and are presumably maintained by the secretion of specific proteins generated in a unique microenvironment or stem cell niche surrounding each population. The relationship between these 2 populations, as well as the cellular sources and composition of the surrounding environment, remains to be defined, and is an active area of research. In this review, we will outline progress in identifying stem cells and in defining epithelial-mesenchymal interactions in the crypt. We will summarize early advances using stem cells for therapy of gastrointestinal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.