Evidence map›Paper›PMID 20801259›Full record

ArticleArchives of physical medicine and rehabilitation2010

Exploratory study on oxygen consumption on-kinetics during treadmill walking in women with systemic lupus erythematosus.

Randall E Keyser, Violeta Rus, Jamal A Mikdashi, Barry S Handwerger

Registry-linked trialAbstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03186794 (Pilot Study Characterizing Aerobic Exercise in Women With Systemic Lupus Erythematosus), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03186794 naterminatednot on this mapstarted 2018, after this paper: background citation

Pilot Study Characterizing Aerobic Exercise in Women With Systemic Lupus Erythematosus (Exercise SLE Pilot).

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2018 to 2021Enrolled24ConditionsSystemic Lupus Erythematosus, Lupus, Autoimmune Disease, Rheumatic DiseaseArmsTreadmill exercise training
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. VOLupus · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Measures of excessPilot and feasibility studies · 2021
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Randall E KeyserGeorge Mason University, Fairfax, VA, USA. rkeyser@gmu.edu
Violeta Rus
Jamal A Mikdashi
Barry S Handwerger
University of Maryland, Baltimore · US

Funding

Disability and Aerobic Capacity in SLER03HD039775 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI KEYSER, RANDALL E · 2001 to 2002
$149k
NICHD NIH HHS 1R03HD39775NICHD NIH HHS R03 HD039775
6 · The paper itself

Abstract

objectiveTo determine whether oxygen consumption (V o(2)) on-kinetics differed between groups of women with systemic lupus erythematosus (SLE) and sedentary but otherwise healthy controls.

designExploratory case-control study.

settingMedical school exercise physiology laboratory.

participantsConvenience samples of women with SLE (n=12) and sedentary but otherwise healthy controls (n=10).

interventionNone.

main outcome measuresV o(2) on-kinetics indices including time to steady state, rate constant, mean response time (MRT), transition constant, and oxygen deficit measured during bouts of treadmill walking at intensities of 3 and 5 metabolic equivalents (METs).

resultsTime to steady state and oxygen deficit were increased and rate constant was decreased in the women with SLE compared with controls. At the 5-MET energy demand, the transition constant was lower and MRT was longer in the women with SLE than in controls. For a similar relative energy expenditure that was slightly lower than the anaerobic threshold, the transition constant was higher in controls than in women with SLE.

conclusionV o(2) on-kinetics was prolonged in women with SLE. The prolongation was concomitant with an increase in oxygen deficit and may underlie performance fatigability in women with SLE.

Indexed as

Exercise ToleranceOxygen ConsumptionAdultAnaerobic ThresholdCase-Control StudiesExercise TestFatigueFemaleHeart RateHumansLupus Erythematosus, SystemicMiddle Aged

Identifiers

PMID20801259
PMCPMC2932474
OpenAlexW2054489710

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.