ReviewRespiratory physiology & neurobiology2010
The role of redox changes in oxygen sensing.
Review in Respiratory physiology & neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Mitochondrial Regulation of the Hypoxia-Inducible Factor in the Development of Pulmonary Hypertension.Journal of clinical medicine · 2022Review
- ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans.PLoS biology · 2022Article
- Important Functions and Molecular Mechanisms of Mitochondrial Redox Signaling in Pulmonary Hypertension.Antioxidants (Basel, Switzerland) · 2022Review
- Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology.Redox biology · 2021Review
- Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.Free radical biology & medicine · 2021Article
- Alteration of miRNA Biogenesis Regulating Proteins in the Human Microglial Cell Line HMC-3 After Ischemic Stress.Molecular neurobiology · 2021Article
- Redox Regulation, Oxidative Stress, and Inflammation in Group 3 Pulmonary Hypertension.Advances in experimental medicine and biology · 2021Review
- Patent ductus arteriosus and oxidative stress in preterm infants: a narrative review.Translational pediatrics · 2020Review
- Hypoxia Signaling in Vascular Homeostasis.Physiology (Bethesda, Md.) · 2018Review
- Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Emerging roles of SIRT1 in fatty liver diseases.International journal of biological sciences · 2017Review
- A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus.Pflugers Archiv : European journal of physiology · 2016Review
- NADPH oxidases-do they play a role in TRPC regulation under hypoxia?Pflugers Archiv : European journal of physiology · 2016Review
- Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension.Free radical biology & medicine · 2015Article
- The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio).The Journal of physiology · 2014Article
- Ceramide mediates acute oxygen sensing in vascular tissues.Antioxidants & redox signaling · 2014Article
- Hypoxia: a master regulator of microRNA biogenesis and activity.Free radical biology & medicine · 2013Review
- Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.American journal of respiratory and critical care medicine · 2013Article
- Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species.Pflugers Archiv : European journal of physiology · 2012Article
- Relationships between vascular oxygen sensing mechanisms and hypertensive disease processes.Hypertension (Dallas, Tex. : 1979) · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The specialized oxygen-sensing tissues include the carotid body and arterial smooth muscle cells in the pulmonary artery (PA) and ductus arteriosus (DA). We discuss the evidence that changes in oxygen tension are sensed through changes in redox status. "Redox" changes imply the giving or accepting of electrons. This might occur through the direct tunneling of electrons from mitochondria or redox couples to an effector protein (e.g. ion channel). Alternatively, the electron might be transferred through reactive oxygen species from mitochondria or an NADPH oxidase isoform. The PA's response to hypoxia and DA's response to normoxia result from reduction or oxidation, respectively. These opposing redox stimuli lead to K+ channel inhibition, membrane depolarization and an increase in cytosolic calcium and/or calcium sensitization that causes contraction. In the neuroendocrine cells (the type 1 cell of the carotid body, neuroepithelial body and adrenomedullary cells), the response is secretion. We examine the roles played by superoxide anion, hydrogen peroxide and the anti-oxidant enzymes in the signaling of oxygen tensions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.