ArticleDevelopmental biology2010
Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos.Communications biology · 2024Article
- Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning.Nature communications · 2023Article
- hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease.Cell stem cell · 2023Article
- Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.Nature communications · 2022Article
- Dynamic 3D Combinatorial Generation of hPSC-Derived Neuromesodermal Organoids With Diverse Regional and Cellular Identities.Current protocols · 2022Article
- Whole-genome sequence analysis reveals selection signatures for important economic traits in Xiang pigs.Scientific reports · 2022Article
- Breaking constraint of mammalian axial formulae.Nature communications · 2022Article
- Limb positioning and initiation: An evolutionary context of pattern and formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Retinoid signaling in skeletal development: Scoping the system for predictive toxicology.Reproductive toxicology (Elmsford, N.Y.) · 2021Review
- Growth differentiation factor 11 locally controls anterior-posterior patterning of the axial skeleton.Journal of cellular physiology · 2019Article
- Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position.Current biology : CB · 2019Article
- GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies.Frontiers in oncology · 2019Review
- Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.PLoS genetics · 2017Article
- Genome-wide study refines the quantitative trait locus for number of ribs in a Large White × Minzhu intercross pig population and reveals a new candidate gene.Molecular genetics and genomics : MGG · 2016Article
- Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.Science (New York, N.Y.) · 2014Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Mice deficient in growth differentiation factor 11 (GDF11) signaling display anterior transformation of axial vertebrae and truncation of caudal vertebrae. However, the in vivo molecular mechanisms by which GDF11 signaling regulates the development of the vertebral column have yet to be determined. We found that Gdf11 and Acvr2b mutants are sensitive to exogenous RA treatment on vertebral specification and caudal vertebral development. We show that diminished expression of Cyp26a1, a retinoic acid inactivating enzyme, and concomitant elevation of retinoic acid activity in the caudal region of Gdf11(-/-) embryos may account for this phenomenon. Reduced expression or function of Cyp26a1 enhanced anterior transformation of axial vertebrae in wild-type and Acvr2b mutants. Furthermore, a pan retinoic acid receptor antagonist (AGN193109) could lessen the anterior transformation phenotype and rescue the tail truncation phenotype of Gdf11(-/-) mice. Taken together, these results suggest that GDF11 signaling regulates development of caudal vertebrae and is involved in specification of axial vertebrae in part by maintaining Cyp26a1 expression, which represses retinoic acid activity in the caudal region of embryos during the somitogenesis stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.