ArticlePain2010
Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion.
Article in Pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- TNF-α Enhanced Activity of Sympathetic Neurons in Superior Cervical Ganglion to Promote Chronic Sleep Deprivation-Related Hyperalgesia.Molecular neurobiology · 2025Article
- Circadian changes of autonomic function in patients with zoster-associated pain: A heart rate variability analysis.Brain and behavior · 2024Article
- The gateway reflex regulates tissue-specific autoimmune diseases.Inflammation and regeneration · 2024Review
- Sympathetic-Sensory Coupling as a Potential Mechanism for Acupoints Sensitization.Journal of pain research · 2023Review
- The structure of sensory afferent compartments in health and disease.Journal of anatomy · 2022Review
- NaJournal of neurophysiology · 2022Article
- Peripheral mechanisms of chronic pain.Medical review (2021) · 2022Review
- Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia.Neuroscience bulletin · 2022Article
- Neuroimmune interactions and osteoarthritis pain: focus on macrophages.Pain reports · 2021Review
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- Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice.Anesthesiology · 2020Article
- Long-term imaging of dorsal root ganglia in awake behaving mice.Nature communications · 2019Article
- Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models.Neuroscience bulletin · 2018Article
- FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons.Pflugers Archiv : European journal of physiology · 2017Article
- Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats.Chinese journal of integrative medicine · 2016Article
- Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays.Journal of neurophysiology · 2016Article
- Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain.Molecular pain · 2015Article
- Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain.Neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many chronic pain conditions including complex regional pain syndrome are exacerbated by sympathetic activity. In animal models, sympathetic fibers sprout into the dorsal root ganglia (DRG) after peripheral nerve injury, forming abnormal connections with sensory neurons. However, functional studies of sympathetic-sensory connections have been limited largely to in vivo studies. This study describes a new method for studying sympathetic-sensory connections in an isolated whole DRG preparation in the rat spinal nerve ligation (SNL) model. Three days after ligation of the ventral ramus of the spinal nerve (SNL), sympathetic fibers sprouting into the DRG were observed to originate largely in the intact dorsal ramus of the spinal nerve, which at the lumbar level is a small branch of the spinal nerve separating from the ventral ramus near the intervertebral foramen. In whole DRG isolated 3 days after SNL, microelectrode recordings of sensory neurons showed that repeated stimulation of the dorsal ramus enhanced spontaneous activity in large and medium diameter neurons and reduced rheobase in large neurons. These effects, which were slow and long lasting, were attributed to stimulation of the sympathetic sprouts because: stimulation had no effect in uninjured DRG; and effects could be reduced or eliminated by a "cocktail" of antagonists of norepinephrine and ATP receptors, by pretreatment with the sympathetic release blocker bretylium, or by pre-cutting the grey ramus through which sympathetic fibers coursed to the ligated DRG. The latter treatment, a relatively minimal form of sympathectomy, was also highly effective in reducing mechanical pain ipsilateral to the SNL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.