ReviewExperimental gerontology2011
Drosophila as a model for age-related impairment in locomotor and other behaviors.
Review in Experimental gerontology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed.
- Cross-species identification of conserved and divergent locomotor kinematic strategies using AutoGaitA.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Age-dependent physiological responses and longevity in three Drosophila species with contrasting lifespans exposed to low temperature and constant darkness.Biogerontology · 2026Article
- Cell-based screen identifies translation state modulators that extend lifespan in Drosophila melanogaster and Caenorhabditis elegans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Chronic exposure to sublethal concentrations of Boral® 500 SC (sulfentrazone) induces sex- and age-dependent metabolic and behavioral effects in Drosophila melanogaster.Environmental science and pollution research international · 2026Article
- Hypergravity exposure leads to persistent effects on geotaxis and activity in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Early-Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies.Aging cell · 2026Article
- The role of genetic variation in shaping phenotypic responses to diet in aging Drosophila melanogaster.Heredity · 2025Article
- Article
- Spermidine supplementation and protein restriction protect from organismal and brain aging independently.Aging · 2025Article
- Hip Adduction Asymmetry in Girls with Adolescent Idiopathic Scoliosis.Journal of clinical medicine · 2025Article
- Loss of Fic causes progressive neurodegeneration in a Drosophila model of hereditary spastic paraplegia.Biochimica et biophysica acta. Molecular basis of disease · 2024Article
- Bugs on Drugs: Paracetamol Exposure Reveals Genotype-Specific Generational Effects on Life History Traits inInsects · 2024Article
- Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex.Biogerontology · 2024Article
- Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster.Aging cell · 2024Article
- The coupling between healthspan and lifespan inAging · 2024Article
- Sickness behaviour and the effect of sex, age, and immune status on individual behavioural variation in Tenebrio molitor.PloS one · 2024Article
- Antioxidant Properties and Geroprotective Potential of Wheat Bran Extracts with Increased Content of Anthocyanins.Antioxidants (Basel, Switzerland) · 2023Article
- Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation.Research square · 2023Article
- Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration.Cell death discovery · 2023Article
- Effects of adenosine receptor overexpression and silencing in neurons and glial cells on lifespan, fitness, and sleep of Drosophila melanogaster.Experimental brain research · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Aging is a multifaceted phenomenon that occurs in most species including humans and the fruit fly, Drosophila melanogaster. One of the most fundamental features of aging is the progressive decline in functional capacity that occurs with age (i.e. functional senescence). Age-related declines in function undermine many aspects of normal youthful physiology including behavior. Age-related behavioral declines are quite telling because they presumably reflect primary functional defects in the nervous system or musculature. Consequently, a more detailed understanding of behavioral declines that occur with age, including mechanisms that impinge on them, could ultimately lead to improved treatment or diagnosis of age-related defects in physiological processes that depend on normal function of the nervous system or musculature. Such advances in diagnosis or treatment would translate into tremendous gains in quality of life for elderly populations. In this article, we review progress using Drosophila to better understand age-related behavioral declines with a focus on age-related locomotor impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.