ArticleBMC neurology2010
Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study.
Article in BMC neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Adding tibial nerve neurodynamic techniques to a rehabilitative pain management strategy improved neuropathy severity and quality of life in patients with diabetic peripheral neuropathy: a randomized sham-controlled trial.BMC complementary medicine and therapies · 2025Trial
- Mechanosensitivity during straight leg raise and slump neurodynamic tests in people with type 1 diabetes mellitus and diabetic peripheral neuropathy.The Journal of manual & manipulative therapy · 2026Article
- Article
- The effectiveness of neurodynamic techniques in patients with diabetic peripheral neuropathy: Study protocol for a randomized sham-controlled trial.Advanced biomedical research · 2024Article
- Effects of Neural Mobilization in Diabetic Peripheral Neuropathy: A Scoping Review.Journal of chiropractic medicine · 2023Article
- Mechanical Effects of a Specific Neurodynamic Mobilization of the Superficial Fibular Nerve: A Cadaveric Study.Journal of athletic training · 2023Article
- Mobilization of the contralateral limb in Slump position: effects on knee extension in healthy adult subjects.Acta bio-medica : Atenei Parmensis · 2019Article
- Effects of dynamic neural mobilization on cerebral cortical activity in patients with stroke.Journal of physical therapy science · 2018Article
- Negative Neurodynamic Tests Do Not Exclude Neural Dysfunction in Patients With Entrapment Neuropathies.Archives of physical medicine and rehabilitation · 2017Article
- Safety of lower extremity neurodynamic exercises in adults with diabetes mellitus: a feasibility study.The Journal of manual & manipulative therapy · 2017Article
- Postural Steadiness and Ankle Force Variability in Peripheral Neuropathy.Motor control · 2016Article
- Effectiveness of manual therapy for cervical radiculopathy, a review.Chiropractic & manual therapies · 2016Review
- Normal inter-limb differences during the straight leg raise neurodynamic test: a cross sectional study.BMC musculoskeletal disorders · 2012Article
- The pattern of tibial nerve excursion with active ankle dorsiflexion is different in older people with diabetes mellitus.Clinical biomechanics (Bristol, Avon) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundType 2 Diabetes Mellitus (T2DM) and diabetic symmetrical polyneuropathy (DSP) impact multiple modalities of sensation including light touch, temperature, position sense and vibration perception. No study to date has examined the mechanosensitivity of peripheral nerves during limb movement in this population. The objective was to determine the unique effects T2DM and DSP have on nerve mechanosensitivity in the lower extremity.
methodsThis cross-sectional study included 43 people with T2DM. Straight leg raise neurodynamic tests were performed with ankle plantar flexion (PF/SLR) and dorsiflexion (DF/SLR). Hip flexion range of motion (ROM), lower extremity muscle activity and symptom profile, intensity and location were measured at rest, first onset of symptoms (P1) and maximally tolerated symptoms (P2).
resultsThe addition of ankle dorsiflexion during SLR testing reduced the hip flexion ROM by 4.3° ± 6.5° at P1 and by 5.4° ± 4.9° at P2. Individuals in the T2DM group with signs of severe DSP (n = 9) had no difference in hip flexion ROM between PF/SLR and DF/SLR at P1 (1.4° ± 4.2°; paired t-test p = 0.34) or P2 (0.9° ± 2.5°; paired t-test p = 0.31). Movement induced muscle activity was absent during SLR with the exception of the tibialis anterior during DF/SLR testing. Increases in symptom intensity during SLR testing were similar for both PF/SLR and DF/SLR. The addition of ankle dorsiflexion induced more frequent posterior leg symptoms when taken to P2.
conclusionsConsistent with previous recommendations in the literature, P1 is an appropriate test end point for SLR neurodynamic testing in people with T2DM. However, our findings suggest that people with T2DM and severe DSP have limited responses to SLR neurodynamic testing, and thus may be at risk for harm from nerve overstretch and the information gathered will be of limited clinical value.
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