ArticleJournal of biomedical optics
Cell deformation cytometry using diode-bar optical stretchers.
Article in Journal of biomedical optics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Harnessing optical forces with advanced nanophotonic structures: principles and applications.Discover nano · 2025Review
- Development of a Pneumatic-Driven Fiber-Shaped Robot Scaffold for Use as a Complex 3D Dynamic Culture System.Biomimetics (Basel, Switzerland) · 2023Article
- Microfluidic techniques for mechanical measurements of biological samples.Biophysics reviews · 2023Review
- Microfluidic technologies for cell deformability cytometry.Smart medicine · 2022Review
- The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip.Micromachines · 2021Review
- A constriction channel analysis of astrocytoma stiffness and disease progression.Biomicrofluidics · 2021Article
- Microfluidic deformability-activated sorting of single particles.Microsystems & nanoengineering · 2020Article
- Cell Nanomechanics Based on Dielectric Elastomer Actuator Device.Nano-micro letters · 2019Review
- Multi-sample deformability cytometry of cancer cells.APL bioengineering · 2018Article
- An Electromagnetically Actuated Double-Sided Cell-Stretching Device for Mechanobiology Research.Micromachines · 2017Article
- Multiparameter mechanical and morphometric screening of cells.Scientific reports · 2016Article
- A Comprehensive Review of Optical Stretcher for Cell Mechanical Characterization at Single-Cell Level.Micromachines · 2016Review
- A comprehensive strategy for the analysis of acoustic compressibility and optical deformability on single cells.Scientific reports · 2016Article
- High-throughput linear optical stretcher for mechanical characterization of blood cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2016Article
- Probing Cell Deformability via Acoustically Actuated Bubbles.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Imaging of a linear diode bar for an optical cell stretcher.Biomedical optics express · 2015Article
- High-Throughput Assessment of Cellular Mechanical Properties.Annual review of biomedical engineering · 2015Review
- Viscoelasticity as a biomarker for high-throughput flow cytometry.Biophysical journal · 2013Article
- A serial micropipette microfluidic device with applications to cancer cell repeated deformation studies.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Measuring cell mechanics by optical alignment compression cytometry.Lab on a chip · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The measurement of cell elastic parameters using optical forces has great potential as a reagent-free method for cell classification, identification of phenotype, and detection of disease; however, the low throughput associated with the sequential isolation and probing of individual cells has significantly limited its utility and application. We demonstrate a single-beam, high-throughput method where optical forces are applied anisotropically to stretch swollen erythrocytes in microfluidic flow. We also present numerical simulations of model spherical elastic cells subjected to optical forces and show that dual, opposing optical traps are not required and that even a single linear trap can induce cell stretching, greatly simplifying experimental implementation. Last, we demonstrate how the elastic modulus of the cell can be determined from experimental measurements of the equilibrium deformation. This new optical approach has the potential to be readily integrated with other cytometric technologies and, with the capability of measuring cell populations, enabling true mechanical-property-based cell cytometry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.