ArticleJournal of biomedical optics
Shack-Hartmann wavefront-sensor-based adaptive optics system for multiphoton microscopy.
Article in Journal of biomedical optics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Tissue type and tissue depth dependency of pulse broadening in three-photon microscopy: impact on third harmonic generation.Biomedical optics express · 2025Article
- Compressive Fourier-Domain Intensity Coupling (C-FOCUS) enables near-millimeter deep imaging in the intact mouse brain in vivo.Research square · 2025Article
- Meta Shack-Hartmann wavefront sensor with large sampling density and large angular field of view: phase imaging of complex objects.Light, science & applications · 2024Article
- Article
- Deep learning-based adaptive optics for light sheet fluorescence microscopy.Biomedical optics express · 2023Article
- Adaptive optics for optical microscopy [Invited].Biomedical optics express · 2023Review
- Recent advances in optical imaging through deep tissue: imaging probes and techniques.Biomaterials research · 2022Review
- Multi-segmented feature coupling for jointly reconstructing initial pressure and speed of sound in photoacoustic computed tomography.Journal of biomedical optics · 2022Article
- Quantitative analysis of illumination and detection corrections in adaptive light sheet fluorescence microscopy.Biomedical optics express · 2022Article
- Review of bio-optical imaging systems with a high space-bandwidth product.Advanced photonics · 2021Article
- Adaptive photoacoustic computed tomography.Photoacoustics · 2021Article
- Laser scanning reflection-matrix microscopy for aberration-free imaging through intact mouse skull.Nature communications · 2020Article
- Practical sensorless aberration estimation for 3D microscopy with deep learning.Optics express · 2020Article
- Adaptive optics two-photon endomicroscopy enables deep-brain imaging at synaptic resolution over large volumes.Science advances · 2020Article
- Advances in adaptive optics-based two-photon fluorescence microscopy for brain imaging.Lasers in medical science · 2020Review
- Automated sensorless single-shot closed-loop adaptive optics microscopy with feedback from computational adaptive optics.Optics express · 2019Article
- Adaptive optical microscopy for neurobiology.Current opinion in neurobiology · 2018Review
- Fabrication of an infrared Shack-Hartmann sensor by combining high-speed single-point diamond milling and precision compression molding processes.Applied optics · 2018Article
- Imaging in turbid media: a transmission detector gives 2-3 order of magnitude enhanced sensitivity compared to epi-detection schemes.Biomedical optics express · 2016Article
- Highly resolved intravital striped-illumination microscopy of germinal centers.Journal of visualized experiments : JoVE · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
The imaging depth of two-photon excitation fluorescence microscopy is partly limited by the inhomogeneity of the refractive index in biological specimens. This inhomogeneity results in a distortion of the wavefront of the excitation light. This wavefront distortion results in image resolution degradation and lower signal level. Using an adaptive optics system consisting of a Shack-Hartmann wavefront sensor and a deformable mirror, wavefront distortion can be measured and corrected. With adaptive optics compensation, we demonstrate that the resolution and signal level can be better preserved at greater imaging depth in a variety of ex-vivo tissue specimens including mouse tongue muscle, heart muscle, and brain. However, for these highly scattering tissues, we find signal degradation due to scattering to be a more dominant factor than aberration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.