Evidence map›Paper›PMID 20799050›Full record

ReviewCellular and molecular life sciences : CMLS2011

Stable transmission of reversible modifications: maintenance of epigenetic information through the cell cycle.

V A Blomen, J Boonstra

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
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  3. Review
  4. Article
  5. Article
  6. Dual modes of DNA NProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Exploration of the Effect on Genome-Wide DNA Methylation byInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Review
  15. Article
  16. Pathophysiology of Type 2 Diabetes Mellitus.International journal of molecular sciences · 2020
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

V A BlomenDepartment of Cellular Dynamics, Faculty of Science, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
J Boonstra

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even though every cell in a multicellular organism contains the same genes, the differing spatiotemporal expression of these genes determines the eventual phenotype of a cell. This means that each cell type contains a specific epigenetic program that needs to be replicated through cell divisions, along with the genome, in order to maintain cell identity. The stable inheritance of these programs throughout the cell cycle relies on several epigenetic mechanisms. In this review, DNA methylation and histone methylation by specific histone lysine methyltransferases (KMT) and the Polycomb/Trithorax proteins are considered as the primary mediators of epigenetic inheritance. In addition, non-coding RNAs and nuclear organization are implicated in the stable transfer of epigenetic information. Although most epigenetic modifications are reversible in nature, they can be stably maintained by self-recruitment of modifying protein complexes or maintenance of these complexes or structures through the cell cycle.

Indexed as

DNA MethylationEpigenesis, GeneticCell CycleChromatin Assembly and DisassemblyDNAEpigenomicsGene SilencingHistone-Lysine N-MethyltransferaseHistonesPolycomb-Group ProteinsRepressor ProteinsDNAHistone-Lysine N-MethyltransferaseHistonesPolycomb-Group ProteinsRepressor Proteins

Identifiers

PMID20799050
PMCPMC3015210

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.