ArticleJournal of molecular evolution2010
Genes devoid of full-length transposable element insertions are involved in development and in the regulation of transcription in human and closely related species.
Article in Journal of molecular evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Localization is the key to action: regulatory peculiarities of lncRNAs.Frontiers in genetics · 2024Review
- Characterization of Transposon-Derived Accessible Chromatin Regions in Rice (International journal of molecular sciences · 2022Article
- The Transposable Element Environment of Human Genes Differs According to Their Duplication Status and Essentiality.Genome biology and evolution · 2021Article
- Does the Presence of Transposable Elements Impact the Epigenetic Environment of Human Duplicated Genes?Genes · 2019Article
- The transposable element environment of human genes is associated with histone and expression changes in cancer.BMC genomics · 2016Article
- Endogenous retroviral promoter exaptation in human cancer.Mobile DNA · 2016Review
- Visualized computational predictions of transcriptional effects by intronic endogenous retroviruses.PloS one · 2013Article
- Evolutionary rate of human tissue-specific genes are related with transposable element insertions.Genetica · 2012Article
- Gene properties and chromatin state influence the accumulation of transposable elements in genes.PloS one · 2012Article
- Nuclear importation of Mariner transposases among eukaryotes: motif requirements and homo-protein interactions.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements (TEs) are major components of mammalian genomes, and their impact on genome evolution is now well established. In recent years several findings have shown that they are associated with the expression level and function of genes. In this study, we analyze the relationships between human genes and full-length TE copies in terms of three factors (gene function, expression level, and selective pressure). We classified human genes according to their TE density, and found that TE-free genes are involved in important functions such as development, transcription, and the regulation of transcription, whereas TE-rich genes are involved in functions such as transport and metabolism. This trend is conserved through evolution. We show that this could be explained by a stronger selection pressure acting on both the coding and non-coding regions of TE-free genes than on those of TE-rich genes. The higher level of expression found for TE-rich genes in tumor and immune system tissues suggests that TEs play an important role in gene regulation.
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