ArticleTetrahedron2010
A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides.
Article in Tetrahedron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Chemical Ligation of Backbone N-hydroxylated Peptides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Native Chemical Ligation to Install Chemical Protein Modifications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Late-Stage Intermolecular O-Peptidylation Protocol Enabled by Sequential Acyl Transfer on Thiol-Incorporated Threonine Followed by Desulfurization.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Uncovering a Latent Bioactive Interleukin-6 Glycoform.Angewandte Chemie (International ed. in English) · 2024Article
- Polypeptide Preparation by β-Lactone-Mediated Chemical Ligation.Organic letters · 2024Article
- Chemical Synthesis of Microtubule-Associated Protein Tau.Journal of the American Chemical Society · 2023Article
- Synthetic Thiol and Selenol Derived Amino Acids for Expanding the Scope of Chemical Protein Synthesis.Frontiers in chemistry · 2021Review
- Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.Organic letters · 2017Article
- A molecular engineering toolbox for the structural biologist.Quarterly reviews of biophysics · 2017Review
- Insights into the deselenization of selenocysteine into alanine and serine.Chemical science · 2015Article
- Total synthesis of glycosylated proteins.Topics in current chemistry · 2015Review
- Application of the protein semisynthesis strategy to the generation of modified chromatin.Annual review of biochemistry · 2015Review
- Realizing serine/threonine ligation: scope and limitations and mechanistic implication thereof.Frontiers in chemistry · 2014Article
- The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.Angewandte Chemie (International ed. in English) · 2013Review
- Expressed protein ligation at methionine: N-terminal attachment of homocysteine, ligation, and masking.Angewandte Chemie (International ed. in English) · 2013Article
- Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141).Angewandte Chemie (International ed. in English) · 2012Article
- At last: erythropoietin as a single glycoform.Angewandte Chemie (International ed. in English) · 2012Article
- Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.Journal of the American Chemical Society · 2012Article
- Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Advances in proline ligation.Journal of the American Chemical Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A method by which to accomplish formal threonine ligation has been developed. The method accomplishes ligations of two peptide domains. We have also demonstrated the ability to successfully ligate two independent glycopeptide domains.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.