ArticleInternational journal of peptides2010
Ghrelin cells in the gastrointestinal tract.
Article in International journal of peptides, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Diagnostic potential of total serum ghrelin in autoimmune gastritis: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Metabolic responses to exogenous ghrelin in obesity and early after Roux-en-Y gastric bypass in humans.Diabetes, obesity & metabolism · 2017Trial
- Spatiotemporal characterization of ghrelin and cholecystokinin levels in the gastrointestinal tract of juvenile SFrontiers in endocrinology · 2026Article
- Gastric dilation following vertical sleeve gastrectomy reflects adaptive stem cell-driven regeneration without association with weight regain or increased cancer risk.Life sciences · 2025Article
- Astrocytes of the hippocampus and responses to periprandial neuroendocrine hormones.Physiology & behavior · 2025Review
- The role of the gastric fundus in glycemic control.Hormones (Athens, Greece) · 2023Review
- Effects ofJournal of clinical medicine · 2022Article
- Role of the Ghrelin System in Colorectal Cancer.International journal of molecular sciences · 2022Review
- Coronary Heart Disease in Type 2 Diabetes Mellitus: Genetic Factors and Their Mechanisms, Gene-Gene, and Gene-Environment Interactions in the Asian Populations.International journal of environmental research and public health · 2022Review
- Contribution of Ghrelin to the Pathogenesis of Growth Hormone Deficiency.International journal of molecular sciences · 2021Review
- Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight.Pharmacological reviews · 2021Review
- Gut peptides and the microbiome: focus on ghrelin.Current opinion in endocrinology, diabetes, and obesity · 2021Review
- Article
- Ghrelin Immunoreactive Cell Amounts in the Abomasum in 4-Month-Old Calves by Feeding Different Amounts of Prebiotics and New Synbiotics.Veterinary medicine international · 2021Article
- Expression of lysine-mediated neuropeptide hormones controlling satiety and appetite in broiler chickens.Poultry science · 2020Article
- Effect of Ghrelin Hormone as a Diagnostic Factor on Appendicitis.Gastroenterology research and practice · 2020Article
- Functional, Diagnostic and Therapeutic Aspects of Gastrointestinal Hormones.Gastroenterology research · 2019Review
- Altered Functional Connectivity of the Amygdala and Sex Differences in Functional Dyspepsia.Clinical and translational gastroenterology · 2019Article
- Ghrelin regulates sepsis‑induced rat acute gastric injury.Molecular medicine reports · 2019Article
- Function and mechanisms of enteroendocrine cells and gut hormones in metabolism.Nature reviews. Endocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ghrelin is 28-amino-acid peptide that was discovered from the rat and human stomach in 1999. Since the discovery of ghrelin, various functions of ghrelin, including growth hormone release, feeding behavior, glucose metabolism, memory, and also antidepressant effects, have been studied. It has also been reported that ghrelin in the gastrointestinal tract has an important physiological effect on gastric acid secretion and gastrointestinal motility. Ghrelin has a unique structure that is modified by O-acylation with n-octanoic acid at third serine residues, and this modification enzyme has recently been identified and named ghrelin O-acyl transferase (GOAT). Ghrelin is considered to be a gut-brain peptide and is abundantly produced from endocrine cells in the gastrointestinal mucosa. In the gastrointestinal tract, ghrelin cells are most abundant in the stomach and are localized in gastric mucosal layers. Ghrelin cells are also widely distributed throughout the gastrointestinal tract. In addition, abundance of ghrelin cells in the gastric mucosa is evolutionally conserved from mammals to lower vertebrates, indicating that gastric ghrelin plays important roles for fundamental physiological functions. Ghrelin cells in the gastrointestinal tract are a major source of circulating plasma ghrelin, and thus understanding the physiology of these cells would reveal the biological significance of ghrelin.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.