ArticleInternational journal of Alzheimer's disease2010
To know or not to know: ethical issues related to early diagnosis of Alzheimer's disease.
Article in International journal of Alzheimer's disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
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Who cites it
29 citing papers in PubMed.
- The word Dementia should be retired.Communications medicine · 2026Article
- More than Just a Game: A Longitudinal Pilot Study on the Outcome Effects of Home-Based Digital Cognitive Rehabilitation in Outpatients with Mild Cognitive Impairment.Brain sciences · 2026Article
- Unresolved ethical questions of mHealth apps for Alzheimer's disease prevention.Medicine, health care, and philosophy · 2025Article
- Alzheimer disease blood biomarkers: considerations for population-level use.Nature reviews. Neurology · 2024Review
- Why to test for dementia: perspectives of patients, significant others and general practitioners.Age and ageing · 2024Article
- Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.Frontiers in medicine · 2024Review
- Understanding patients' and significant others' preferences on starting a diagnostic trajectory for dementia: An integrative review.Aging & mental health · 2023Review
- Using the Montreal cognitive assessment to identify individuals with subtle cognitive decline.Neuropsychology · 2022Article
- Article
- Ethical Implications of Alzheimer's Disease Prediction in Asymptomatic Individuals through Artificial Intelligence.Diagnostics (Basel, Switzerland) · 2021Article
- Specialist approaches to prognostic counseling in isolated REM sleep behavior disorder.Sleep medicine · 2021Article
- REM Sleep Behavior Disorder as a Pathway to Dementia: If, When, How, What, and Why Should Physicians Disclose the Diagnosis and Risk for Dementia.Current sleep medicine reports · 2021Review
- Primary Prevention of Dementia: An Ethical Review.Journal of Alzheimer's disease : JAD · 2021Review
- European Psychiatric Association policy paper on ethical aspects in communication with patients and their families.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Communicating uncertainties when disclosing diagnostic test results for (Alzheimer's) dementia in the memory clinic: The ABIDE project.Health expectations : an international journal of public participation in health care and health policy · 2020Observational
- General practitioners' attitudes towards early diagnosis of dementia: a cross-sectional survey.BMC family practice · 2019Article
- Using Cerebrospinal Fluid Biomarker Testing to Target Treatment to Patients with Mild Cognitive Impairment: A Cost-Effectiveness Analysis.PharmacoEconomics - open · 2018Article
- Review of the Ethical Issues of a Biomarker-Based Diagnoses in the Early Stage of Alzheimer's Disease.Journal of bioethical inquiry · 2018Review
- Completed suicide in an autopsy-confirmed case of early onset Alzheimer's disease.Neurodegenerative disease management · 2018Article
- Advance directives as a tool to respect patients' values and preferences: discussion on the case of Alzheimer's disease.BMC medical ethics · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Alzheimer's disease (AD), pathological processes start in the brain long before clinical dementia. Biomarkers reflecting brain alterations may therefore indicate disease at an early stage, enabling early diagnosis. This raises several ethical questions and the potential benefits of early diagnosis must be weighted against possible disadvantages. Currently, there are few strong arguments favouring early diagnosis, due to the lack of disease modifying therapy. Also, available diagnostic methods risk erroneous classifications, with potentially grave consequences. However, a possible benefit of early diagnosis even without disease modifying therapy is that it may enable early decision making when patients still have full decision competence, avoiding problems of hypothetical consents. It may also help identifying patients with cognitive dysfunction secondary to other diseases that may be responsive to treatment already today.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.