ArticleCommunicative & integrative biology2010
Competition-colonization dynamics: An ecology approach to quasispecies dynamics and virulence evolution in RNA viruses.
Article in Communicative & integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Haploflow: strain-resolved de novo assembly of viral genomes.Genome biology · 2021Article
- Haploflow: Strain-resolvedbioRxiv : the preprint server for biology · 2021Article
- Concerns and public health challenges for arboviral and other respiratory infections amidst SARS-CoV-2 pandemic.Pathogens and global health · 2020Article
- Virological and Immunological Outcomes of Coinfections.Clinical microbiology reviews · 2018Review
- Differential Persistence of Foot-and-Mouth Disease Virus in African Buffalo Is Related to Virus Virulence.Journal of virology · 2016Article
- Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy.Scientific reports · 2015Article
- Competition-colonization trade-off promotes coexistence of low-virulence viral strains.Journal of the Royal Society, Interface · 2012Article
- Quasispecies as a matter of fact: viruses and beyond.Virus research · 2011Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A single and purified clone of foot-and-mouth disease virus diversified in cell culture into two subpopulations that were genetically distinct. The subpopulation with higher virulence was a minority and was suppressed by the dominant but less virulent one. These two populations follow the competitioncolonization dynamics described in ecology. Virulent viruses can be regarded as colonizers because they killed the cells faster and they spread faster. The attenuated subpopulation resembles competitors because of its higher replication efficiency in coinfected cells. Our results suggest a new model for the evolution of virulence which is based on interactions between components of the quasispecies. Competition between viral mutants takes place at two levels, intracellular competition and competition for new cells. The two strategies are subjected to densitydependent selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.