Evidence map›Paper›PMID 20798607›Full record

ArticleFly

Satellite signaling at synapses.

Kate M O'Connor-Giles, Barry Ganetzky

Open access · bronzeAbstract read
In one paragraph

Article in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Glutamatergic Synapse Dysfunction inFrontiers in molecular neuroscience · 2022
    Article
  5. Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kate M O'Connor-GilesLaboratory of Genetics, University of Wisconsin - Madison, Madison, Wisconsin 53706, USA. oconnorgiles@wisc.edu
Barry Ganetzky
University of Wisconsin–Madison · US

Funding

Neurogenetics of TS-Paralytic Mutants in DrosophilaR01NS015390 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GANETZKY, BARRY S · 1985 to 2011
$4.5M
Regulation of synaptic growth and plasticity in DrosophilaR00NS060985 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR-GILES, KATHALEEN M · 2009 to 2011
$747k
Regulation of synaptic growth and plasticity in DrosophilaK99NS060985 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR-GILES, KATHALEEN M · 2008 to 2008
$89k
NINDS NIH HHS K99 NS060985NINDS NIH HHS NS015390NINDS NIH HHS NS060985NINDS NIH HHS R00 NS060985NINDS NIH HHS R01 NS015390
6 · The paper itself

Abstract

Neural function requires effective communication between neurons and their targets at synapses. Thus, proper formation, growth and plasticity of synapses are critical to behavior. A retrograde (muscle to neuron) BMP signal is required to promote synaptic growth, homeostasis and stability at Drosophila neuromuscular junctions (NMJs).(1-4) We recently demonstrated that this signal constitutes an instructive signal that sculpts synaptic growth in a graded manner and uncovered a presynaptic endocytic mechanism that modulates BMP signaling levels. In the absence of this regulation, excessive BMP signaling results in overgrown NMJs with a proliferation of ectopic boutons.(5).

Indexed as

AnimalsDrosophilaDrosophila ProteinsModels, NeurologicalMusclesNerve Tissue ProteinsNeuromuscular JunctionNeuronsSignal TransductionSynapsesDrosophila ProteinsNerve Tissue Proteinsnwk protein, Drosophila

Identifiers

PMID20798607
PMCPMC3744159
OpenAlexW1969651010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.