ArticleProceedings of the National Academy of Sciences of the United States of America2010
BK channels play a counter-adaptive role in drug tolerance and dependence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice.Molecular psychiatry · 2024Article
- Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking.Translational psychiatry · 2023Article
- Receptors and Channels Associated with Alcohol Use: Contributions fromNeuroscience insights · 2021Review
- Flying Together:International journal of molecular sciences · 2020Review
- Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance.Genes, brain, and behavior · 2019Article
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking.Alcohol (Fayetteville, N.Y.) · 2017Article
- Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP.Frontiers in molecular neuroscience · 2017Article
- Alcohol Regulates BK Surface Expression via Wnt/β-Catenin Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness.Oncotarget · 2016Article
- A DNA element in the slo gene modulates ethanol tolerance.Alcohol (Fayetteville, N.Y.) · 2016Article
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
- Modulation of BK Channels by Ethanol.International review of neurobiology · 2016Review
- A histone modification identifies a DNA element controlling slo BK channel gene expression in muscle.Journal of neurogenetics · 2015Article
- An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Alcohol withdrawal is associated with a downregulation of large-conductance Ca²⁺-activated K⁺ channels in rat inferior colliculus neurons.Psychopharmacology · 2014Article
- Susceptibility to ethanol withdrawal seizures is produced by BK channel gene expression.Addiction biology · 2014Article
- Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior.Frontiers in physiology · 2014Review
- The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies.Frontiers in physiology · 2014Review
- Functional mapping of the neuronal substrates for drug tolerance in Drosophila.Behavior genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Disturbance of neural activity by sedative drugs has been proposed to trigger a homeostatic response that resists unfavorable changes in net cellular excitability, leading to tolerance and dependence. The Drosophila slo gene encodes a BK-type Ca(2+)-activated K(+) channel implicated in functional tolerance to alcohol and volatile anesthetics. We hypothesized that increased expression of BK channels induced by these drugs constitutes the homeostatic adaptation conferring resistance to sedative drugs. In contrast to the dogmatic view that BK channels act as neural depressants, we show that drug-induced slo expression enhances excitability by reducing the neuronal refractory period. Although this neuroadaptation directly counters some effects of anesthetics, it also causes long-lasting enhancement of seizure susceptibility, a common symptom of drug withdrawal. These data provide a possible mechanism for the long-standing counter-adaptive theory for drug tolerance in which homeostatic adaptations triggered by drug exposure to produce drug tolerance become counter-adaptive after drug clearance and result in symptoms of dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.