ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Infant cortisol stress-response is associated with thymic function and vaccine response.Stress (Amsterdam, Netherlands) · 2019Trial
- Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging.Science advances · 2026Article
- Sex hormones and gender differences in immune responses and anticancer immunity: a comprehensive review.Biologia futura · 2026Review
- Immunosenescence and organoids: pathophysiology and therapeutic opportunities.Immunity & ageing : I & A · 2025Review
- Heterogeneity of thymic output in the elderly and its association with sex and smoking.JCI insight · 2025Article
- Endogenous thymic regeneration: restoring T cell production following injury.Nature reviews. Immunology · 2025Review
- The Similarities and Differences between the Effects of Testosterone and DHEA on the Innate and Adaptive Immune Response.Biomolecules · 2022Review
- Glucocorticoid production in the thymus and brain: Immunosteroids and neurosteroids.Brain, behavior, & immunity - health · 2021Article
- Recent Advancements in Regenerative Approaches for Thymus Rejuvenation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Glucocorticoids in T cell development, differentiation and function.Nature reviews. Immunology · 2021Review
- Reproductive Suicide: Similar Mechanisms of Aging inFrontiers in cell and developmental biology · 2021Article
- Sex Differences in the Immune System Become Evident in the Perinatal Period in the Four Core Genotypes Mouse.Frontiers in endocrinology · 2021Article
- Infection-Associated Thymic Atrophy.Frontiers in immunology · 2021Review
- Article
- Thymic activity in immune recovery after allogeneic hematopoietic stem cell transplantation in children.Central-European journal of immunology · 2020Article
- Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice.Frontiers in immunology · 2020Article
- Analysis of Corticosterone and Testosterone Synthesis in Rat Salivary Gland Homogenates.Frontiers in endocrinology · 2019Article
- Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Glucocorticoids, Sex Hormones, and Immunity.Frontiers in immunology · 2018Review
- T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites.Cell death & disease · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Androgens contribute to the involution process of the aging thymus gland. However, molecular mechanisms behind this effect remain largely unknown. We have investigated the influence of testosterone on the ectopic synthesis of glucocorticoids (GCs) in thymocytes, an activity recently shown by us to be important for the homeostatic regulation of these cells. Castration, which leads to a strong increase in thymus tissue and function, was associated with a reduced GC release from thymocytes caused by down-regulated expression of several enzymes involved in GC synthesis, without affecting GC synthesis in the adrenals. Testosterone treatment of castrated male mice reversed these effects, also without affecting adrenal GC synthesis. The effects of testosterone in castrated mice on thymocyte homeostasis and GC release were strongly reduced in mice pretreated with the CYP11B1 enzyme inhibitor metyrapone, acting on the last step in the corticosterone synthesis. The androgen-induced thymic involution was dependent on GC action, because this was completely absent in mice lacking GC receptor (GR) expression specifically in thymocytes. We provide here an unrecognized mechanism how androgens contribute to thymic involution by stimulating local synthesis and release of GCs in the thymus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.