ArticleMicrobiology (Reading, England)2010
Role of Hcp, a type 6 secretion system effector, of Aeromonas hydrophila in modulating activation of host immune cells.
Article in Microbiology (Reading, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
- Analysis of globalMicrobial genomics · 2024Article
- Effector protein Hcp2a of avian pathogenic Escherichia coli interacts with the endoplasmatic reticulum associated RPL23 protein of chicken DF-1 fibroblasts.Veterinary research · 2023Article
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- Hcp Proteins of the Type VI Secretion System Promote Avian PathogenicLife (Basel, Switzerland) · 2022Article
- Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis.Infection and immunity · 2022Review
- TheFrontiers in cellular and infection microbiology · 2022Article
- Immune Response of the Monocytic Cell Line THP-1 Against SixFrontiers in immunology · 2022Article
- A Standardized Extract ofFrontiers in microbiology · 2022Article
- Article
- Characterization of Lysozyme-Like Effector TseP Reveals the Dependence of Type VI Secretion System (T6SS) Secretion on Effectors in Aeromonas dhakensis Strain SSU.Applied and environmental microbiology · 2021Article
- In silico comparative analysis of Aeromonas Type VI Secretion System.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Prediction and AnalysisFrontiers in microbiology · 2021Article
- Type VI secretion systems of plant-pathogenic Burkholderia glumae BGR1 play a functionally distinct role in interspecies interactions and virulence.Molecular plant pathology · 2020Article
- T6SS and ExoA of flesh-eatingProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Diffusely AdherentInfection and immunity · 2019Article
- Comparative genomics of Aeromonas veronii: Identification of a pathotype impacting aquaculture globally.PloS one · 2019Article
- Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli.Emerging microbes & infections · 2018Article
- Comparative Genomics ofFrontiers in microbiology · 2018Article
- Role of the Genes of Type VI Secretion System in Virulence of Rice Bacterial Brown Stripe Pathogen Acidovorax avenae subsp. avenae Strain RS-2.International journal of molecular sciences · 2017Article
- Identification of New Virulence Factors and Vaccine Candidates forFrontiers in cellular and infection microbiology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recently, we reported that the type 6 secretion system (T6SS) of Aeromonas hydrophila SSU plays an important role in bacterial virulence in a mouse model, and immunization of animals with the T6SS effector haemolysin co-regulated protein (Hcp) protected them against lethal infections with wild-type bacteria. Additionally, we showed that the mutant bacteria deleted for the vasH gene within the T6SS gene cluster did not express the hcp gene, while the vasK mutant could express and translocate Hcp, but was unable to secrete it into the extracellular milieu. Both of these A. hydrophila SSU mutants were readily phagocytosed by murine macrophages, pointing to the possible role of the secreted form of Hcp in the evasion of the host innate immunity. By using the ΔvasH mutant of A. hydrophila, our in vitro data showed that the addition of exogenous recombinant Hcp (rHcp) reduced bacterial uptake by macrophages. These results were substantiated by increased bacterial virulence when rHcp was added along with the ΔvasH mutant in a septicaemic mouse model of infection. Analysis of the cytokine profiling in the intraperitoneal lavage as well as activation of host cells after 4 h of infection with the ΔvasH mutant supplemented with rHcp indicated that this T6SS effector inhibited production of pro-inflammatory cytokines and induced immunosuppressive cytokines, such as interleukin-10 and transforming growth factor-β, which could circumvent macrophage activation and maturation. This mechanism of innate immune evasion by Hcp possibly inhibited the recruitment of cellular immune components, which allowed bacterial multiplication and dissemination in animals, thereby leading to their mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.