ArticleProceedings of the National Academy of Sciences of the United States of America2010
Functional interactions between membrane-bound transporters and membranes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- ATP synthase activity boosts membrane proton acceptance and lateral diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Proton Migration on Top of Charged Membranes.Biomolecules · 2023Article
- Enzymatic Approach in Calcium Phosphate Biomineralization: A Contribution to Reconcile the Physicochemical with the Physiological View.International journal of molecular sciences · 2021Review
- Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Competing for the same space: protons and alkali ions at the interface of phospholipid bilayers.Biophysical reviews · 2019Review
- Exploring fast proton transfer events associated with lateral proton diffusion on the surface of membranes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Structure of a functional obligate complex IIINature structural & molecular biology · 2018Article
- The electron distribution in the "activated" state of cytochrome c oxidase.Scientific reports · 2018Article
- Interfacial water molecules at biological membranes: Structural features and role for lateral proton diffusion.PloS one · 2018Article
- Origin of proton affinity to membrane/water interfaces.Scientific reports · 2017Article
- The lateral distance between a proton pump and ATP synthase determines the ATP-synthesis rate.Scientific reports · 2017Article
- Proton Transport Mechanism of M2 Proton Channel Studied by Laser-Induced pH Jump.Journal of the American Chemical Society · 2017Article
- Protons and Hydroxide Ions in Aqueous Systems.Chemical reviews · 2016Review
- Lipid-mediated Protein-protein Interactions Modulate Respiration-driven ATP Synthesis.Scientific reports · 2016Article
- The limits of chemosensation vary across dimensions.Nature communications · 2015Article
- Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Alkaliphilic Bacteria with Impact on Industrial Applications, Concepts of Early Life Forms, and Bioenergetics of ATP Synthesis.Frontiers in bioengineering and biotechnology · 2015Review
- Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer.FEBS letters · 2012Article
- Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
One key role of many cellular membranes is to hold a transmembrane electrochemical ion gradient that stores free energy, which is used, for example, to generate ATP or to drive transmembrane transport processes. In mitochondria and many bacteria, the gradient is maintained by proton-transport proteins that are part of the respiratory (electron-transport) chain. Even though our understanding of the structure and function of these proteins has increased significantly, very little is known about the specific role of functional protein-membrane and membrane-mediated protein-protein interactions. Here, we have investigated the effect of membrane incorporation on proton-transfer reactions within the membrane-bound proton pump cytochrome c oxidase. The results show that the membrane acts to accelerate proton transfer into the enzyme's catalytic site and indicate that the intramolecular proton pathway is wired via specific amino acid residues to the two-dimensional space defined by the membrane surface. We conclude that the membrane not only acts as a passive barrier insulating the interior of the cell from the exterior solution, but also as a component of the energy-conversion machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.