ArticleProceedings of the National Academy of Sciences of the United States of America2010
Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 104 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
104 citing papers in PubMed, 194 citations in OpenAlex.
- Trial
- RETRACTED: A 12,800-year-old layer with cometary dust, microspherules, and platinum anomaly recorded in multiple cores from Baffin Bay.PloS one · 2025Article
- Application of iron oxide nanoparticles in the diagnosis and treatment of leukemia.Frontiers in pharmacology · 2023Review
- Fake Science: XMRV, COVID-19, and the Toxic Legacy of Dr. Judy Mikovits.AIDS research and human retroviruses · 2020Article
- Problems with precaution: the transfusion medicine experience.Journal of risk research · 2019Article
- Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Journal of translational medicine · 2018Review
- XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR, and Its Association with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Appears Unreliable.Frontiers in public health · 2017Article
- Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply.Clinical microbiology reviews · 2016Review
- Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).Expert review of clinical pharmacology · 2016Review
- Article
- Article
- The saga of XMRV: a virus that infects human cells but is not a human virus.Emerging microbes & infections · 2014Review
- Lack of evidence for retroviral infections formerly related to chronic fatigue in Spanish fibromyalgia patients.Virology journal · 2013Article
- Blood system changes since recognition of transfusion-associated AIDS.Transfusion · 2013Article
- Partial molecular cloning of the JHK retrovirus using gammaretrovirus consensus PCR primers.Future virology · 2013Article
- No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2013Article
- Emerging infectious agents and the nation's blood supply: responding to potential threats in the 21st century.Transfusion · 2013Article
- Infection of Xenotransplanted Human Cell Lines by Murine Retroviruses: A Lesson Brought Back to Light by XMRV.Frontiers in oncology · 2013Article
- No evidence of xenotropic murine leukaemia virus-related virus in French blood donors.Blood transfusion = Trasfusione del sangue · 2012Article
- Emerging pathogens and their implications for the blood supply and transfusion transmitted infections.British journal of haematology · 2012Review
44 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2011-12-27Concerns/Issues about Results and/or Conclusions · Results Not Reproducible ·
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- Erratum issued
- Retracted
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any murine leukemia virus (MLV)-related virus gene sequences in blood of CFS patients. We examined 41 PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse DNA contamination was detected in the PCR assay system or the clinical samples. Seven of 8 gag-positive patients tested again positive in a sample obtained nearly 15 y later. In contrast to the reported findings of near-genetic identity of all XMRVs, we identified a genetically diverse group of MLV-related viruses. The gag and env sequences from CFS patients were more closely related to those of polytropic mouse endogenous retroviruses than to those of XMRVs and were even less closely related to those of ecotropic MLVs. Further studies are needed to determine whether the same strong association with MLV-related viruses is found in other groups of patients with CFS, whether these viruses play a causative role in the development of CFS, and whether they represent a threat to the blood supply.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.