ArticleProceedings of the National Academy of Sciences of the United States of America2010
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 95 citations in OpenAlex.
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- The relationship of redox signaling with the risk for atherosclerosis.Frontiers in pharmacology · 2024Review
- Nonmetabolic role for CKB in ferroptosis.Nature cell biology · 2023Article
- Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis.Cell death and differentiation · 2023Article
- Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses.Frontiers in nutrition · 2023Review
- Ferroptosis: machinery and regulation.Autophagy · 2021Review
- Glutaredoxin: Discovery, redox defense and much more.Redox biology · 2021Review
- Redox regulation of tumor suppressor PTEN in cell signaling.Redox biology · 2020Review
- Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism.Cell death and differentiation · 2020Article
- CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.Molecular cancer · 2020Article
- The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-β1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers.Investigational new drugs · 2019Article
- Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion.Nature reviews. Cancer · 2019Review
- Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid.Oxidative medicine and cellular longevity · 2019Article
- Redox Regulation Beyond ROS: Why ROS Should Not Be Measured as Often.Circulation research · 2018Review
- Regulation of lipid peroxidation and ferroptosis in diverse species.Genes & development · 2018Review
- Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System.Antioxidants & redox signaling · 2017Review
- Redox Regulation of the Tumor Suppressor PTEN by Hydrogen Peroxide and Tert-Butyl Hydroperoxide.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein tyrosine phosphatases (PTPs) are regulated through reversible oxidation of the active-site cysteine. Previous studies have implied soluble reactive oxygen species (ROS), like H(2)O(2), as the mediators of PTP oxidation. The potential role(s) of peroxidized lipids in PTP oxidation have not been described. This study demonstrates that increases in cellular lipid peroxides, induced by disruption of glutathione peroxidase 4, induce cellular PTP oxidation and reduce the activity of PDGF receptor targeting PTPs. These effects were accompanied by site-selective increased PDGF beta-receptor phosphorylation, sensitive to 12/15-lipoxygenase (12/15-LOX) inhibitors, and increased PDGF-induced cytoskeletal rearrangements. Importantly, the 12/15-LOX-derived 15-OOH-eicosatetraenoic acid lipid peroxide was much more effective than H(2)O(2) in induction of in vitro PTP oxidation. Our study thus establishes that lipid peroxides are previously unrecognized inducers of oxidation of PTPs. This identifies a pathway for control of receptor tyrosine kinase signaling, which might also be involved in the etiology of diseases associated with increased lipid peroxidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.