ArticleJournal of psychiatric research2011
Thalamic morphology in schizophrenia and schizoaffective disorder.
Article in Journal of psychiatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Ketamine-Induced Modulation of the Thalamo-Cortical Network in Healthy Volunteers As a Model for Schizophrenia.The international journal of neuropsychopharmacology · 2015Trial
- Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.PloS one · 2013Trial
- Difference in Laterality of the Dorsal Striatum in Schizoaffective Disorder.Actas espanolas de psiquiatria · 2024Article
- Altered brain connectivity during visual stimulation in schizophrenia.Experimental brain research · 2022Article
- Altered asymmetries of resting-state MRI in the left thalamus of first-episode schizophrenia.Chronic diseases and translational medicine · 2022Article
- Insula volumes in patients with schizoaffective disorder.Actas espanolas de psiquiatria · 2022Article
- Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia.Psychiatry research. Neuroimaging · 2021Article
- A Diagnosis and Biotype Comparison Across the Psychosis Spectrum: Investigating Volume and Shape Amygdala-Hippocampal Differences from the B-SNIP Study.Schizophrenia bulletin · 2021Article
- A Case for Thalamic Mechanisms of Schizophrenia: Perspective From Modeling 22q11.2 Deletion Syndrome.Frontiers in neural circuits · 2021Review
- Cannabis use in patients with early psychosis is associated with alterations in putamen and thalamic shape.Human brain mapping · 2020Article
- Partial-volume modeling reveals reduced gray matter in specific thalamic nuclei early in the time course of psychosis and chronic schizophrenia.Human brain mapping · 2020Article
- Enhanced Connectivity of Thalamo-Cortical Networks in First-Episode, Treatment-Naive Somatization Disorder.Frontiers in psychiatry · 2020Article
- Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study.Journal of clinical imaging science · 2019Article
- Effects of neonatal excitotoxic lesions in ventral thalamus on social interaction in the rat.European archives of psychiatry and clinical neuroscience · 2018Article
- Progressive deterioration of thalamic nuclei relates to cortical network decline in schizophrenia.Schizophrenia research · 2017Article
- First- and second-generation antipsychotic drug treatment and subcortical brain morphology in schizophrenia.European archives of psychiatry and clinical neuroscience · 2016Article
- Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder.Acta psychiatrica Scandinavica · 2016Article
- Northwestern University schizophrenia data sharing for SchizConnect: A longitudinal dataset for large-scale integration.NeuroImage · 2016Article
- Subcortical neuromorphometry in schizophrenia spectrum and bipolar disorders.NeuroImage. Clinical · 2016Article
- A comparative analysis of mouse and human medial geniculate nucleus connectivity: a DTI and anterograde tracing study.NeuroImage · 2015Article
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Authors and funding
6 authors.
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Abstract
backgroundBiomarkers are needed that can distinguish between schizophrenia and schizoaffective disorder to inform the ongoing debate over the diagnostic boundary between these two disorders. Neuromorphometric abnormalities of the thalamus have been reported in individuals with schizophrenia and linked to core features of the disorder, but have not been similarly investigated in individuals with schizoaffective disorder. In this study, we examine whether individuals with schizoaffective disorder have a pattern of thalamic deformation that is similar or different to the pattern found in individuals with schizophrenia.
methodT1-weighted magnetic resonance images were collected from individuals with schizophrenia (n = 47), individuals with schizoaffective disorder (n = 15), and controls (n = 42). Large-deformation, high-dimensional brain mapping was used to obtain three-dimensional surfaces of the thalamus. Multiple analyses of variance were used to test for group differences in volume and measures of surface shape.
resultsIndividuals with schizophrenia or schizoaffective disorder have similar thalamic volumes. Thalamic surface shape deformation associated with schizophrenia suggests selective involvement of the anterior and posterior thalamus, while deformations in mediodorsal and ventrolateral regions were observed in both groups. Schizoaffective disorder had distinct deformations in medial and lateral thalamic regions.
conclusionsAbnormalities distinct to schizoaffective disorder suggest involvement of the central and ventroposterior medial thalamus which may be involved in mood circuitry, dorsolateral nucleus which is involved in recall processing, and the lateral geniculate nucleus which is involved in visual processing.
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