ArticleThe Journal of pediatrics2010
Endocrine dysfunction following traumatic brain injury in children.
Article in The Journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Pituitary function after moderate or severe traumatic brain injury in two pediatric reference centers in Bogotá D.C, Colombia.European journal of pediatrics · 2026Observational
- Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions.Children (Basel, Switzerland) · 2025Review
- Systemic IGF-1 administration prevents traumatic brain injury induced gut permeability, dysmorphia, dysbiosis, and the increased number of immature dentate granule cells.Acta neuropathologica communications · 2025Article
- New diagnostic approach to central hypothyroidism after traumatic brain injury in children and adolescents.European thyroid journal · 2025Article
- An Approach to Traumatic Brain Injury-Related Hypopituitarism: Overcoming the Pediatric Challenges.Diagnostics (Basel, Switzerland) · 2023Article
- Central Diabetes Insipidus in Children and Adolescents: Twenty-Six Year Experience from a Single Centre.International journal of endocrinology · 2022Article
- A Pro-social Pill? The Potential of Pharmacological Treatments to Improve Social Outcomes After Pediatric Traumatic Brain Injury.Frontiers in neurology · 2021Review
- Evidence Limitations in Determining Sexually Dimorphic Outcomes in Pediatric Post-Traumatic Hypopituitarism and the Path Forward.Frontiers in neurology · 2020Review
- Lifelong consequences of brain injuries during development: From risk to resilience.Frontiers in neuroendocrinology · 2019Review
- The frequency and the diagnosis of pituitary dysfunction after traumatic brain injury.Pituitary · 2019Review
- Should We Assess Pituitary Function in Children After a Mild Traumatic Brain Injury? A Prospective Study.Frontiers in endocrinology · 2019Article
- Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona.Frontiers in neurology · 2019Article
- Pituitary insufficiency following traumatic thoracic injury in an adolescent male patient: A case report and literature review.Medicine · 2017Review
- Altered stress system reactivity after pediatric injury: Relation with post-traumatic stress symptoms.Psychoneuroendocrinology · 2017Observational
- Endocrine dysfunction following traumatic brain injury: a 5-year follow-up nationwide-based study.Scientific reports · 2016Article
- Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury.Journal of clinical medicine · 2015Review
- Substance p regulates puberty onset and fertility in the female mouse.Endocrinology · 2015Article
- Prospective investigation of anterior pituitary function in the acute phase and 12 months after pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Hypopituitarism in pediatric survivors of inflicted traumatic brain injury.Journal of neurotrauma · 2014Article
- Is routine endocrine evaluation necessary after paediatric traumatic brain injury?Journal of endocrinological investigation · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo identify the incidence of endocrine dysfunction in children following traumatic brain injury (TBI). STUDY
designThis was a prospective evaluation of 31 children after TBI. Inclusion criteria included Glasgow Coma Scale score ≤ 12 and age 1.5-18 years. We evaluated thyroid function, insulin-like growth factor I, insulin-like growth factor-binding protein 3, and cortisol at 1, 3, 6, and 12 months after injury, and assessed prolactin at 3 and 6 months. At 6 months, we also assessed overnight spontaneous growth hormone secretion, nocturnal thyrotropin surge, adrenal reserve, and serum and urine osmolarity.
resultsThe average patient age was 11.6 years, and mean Glascow Coma Scale score was 6. The incidence of endocrine dysfunction was 15% at 1 month, 75% at 6 months, and 29% at 12 months. At 12 months after injury, 14% had precocious puberty, 9% had hypothyroidism, and 5% had growth hormone deficiency. Endocrine dysfunction at 1 year did not correlate with the severity of injury.
conclusionsEndocrine dysfunction after TBI is common in children, but most cases resolve by 1 year. We recommend endocrine surveillance at both 6 and 12 months following moderate or severe TBI to ensure early intervention for persistent or late-occurring endocrine sequelae.
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20797728What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.