ArticleChemistry & biology2010
The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice.
Article in Chemistry & biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
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- An improved UPLC-MS/MS platform for quantitative analysis of glycerophosphoinositol in mammalian cells.PloS one · 2015Article
- Brain region mapping using global metabolomics.Chemistry & biology · 2014Article
- Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity.Chemistry & biology · 2014Article
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- Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.ACS chemical biology · 2014Article
- Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- An untargeted metabolomic workflow to improve structural characterization of metabolites.Analytical chemistry · 2013Article
- Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure.Metabolomics : Official journal of the Metabolomic Society · 2013Article
- Therapeutic potential of monoacylglycerol lipase inhibitors.Life sciences · 2013Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
GDE1 is a mammalian glycerophosphodiesterase (GDE) implicated by in vitro studies in the regulation of glycerophophoinositol (GroPIns) and possibly other glycerophospho (GroP) metabolites. Here, we show using untargeted metabolomics that GroPIns is profoundly (>20-fold) elevated in brain tissue from GDE1(-/-) mice. Furthermore, two additional GroP metabolites not previously identified in eukaryotic cells, glycerophosphoserine (GroPSer) and glycerophosphoglycerate (GroPGate), were also highly elevated in GDE1(-/-) brains. Enzyme assays with synthetic GroP metabolites confirmed that GroPSer and GroPGate are direct substrates of GDE1. Interestingly, our metabolomic profiles also revealed that serine (both L-and D-) levels were significantly reduced in brains of GDE1(-/-) mice. These findings designate GroPSer as a previously unappreciated reservoir for free serine in the nervous system and suggest that GDE1, through recycling serine from GroPSer, may impact D-serine-dependent neural signaling processes in vivo.
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