ArticleReproductive biology and endocrinology : RB&E2010
Autocrine regulation of human sperm motility by tachykinins.
Article in Reproductive biology and endocrinology : RB&E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- A comprehensive review of the literature on CD10: its function, clinical application, and prospects.Frontiers in pharmacology · 2024Review
- Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.Frontiers in endocrinology · 2022Review
- (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability.International journal of molecular sciences · 2021Article
- Regulation of Male Fertility by the Renin-Angiotensin System.International journal of molecular sciences · 2020Review
- Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility.International journal of molecular sciences · 2020Review
- Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men.International journal of fertility & sterility · 2020Article
- Tachykinins and Kisspeptins in the Regulation of Human Male Fertility.Journal of clinical medicine · 2019Review
- Identification and characterization of RSIY-11, a novel seminal peptide derived from semenogelin-1, which acts as a neutral endopeptidase inhibitor modulating sperm motility.Journal of assisted reproduction and genetics · 2019Article
- Article
- Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.Frontiers in neuroscience · 2019Review
- Peptides in seminal fluid and their role in infertility: a potential role for opiorphin inhibition of neutral endopeptidase activity as a clinically relevant modulator of sperm motility: a review.Reproductive sciences (Thousand Oaks, Calif.) · 2014Review
- Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model.BMC musculoskeletal disorders · 2014Article
- Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.Physiological reviews · 2014Review
- Central hypogonadotropic hypogonadism: genetic complexity of a complex disease.International journal of endocrinology · 2014Review
- Bilateral increase in expression and concentration of tachykinin in a unilateral rabbit muscle overuse model that leads to myositis.BMC musculoskeletal disorders · 2013Article
- GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity.Frontiers in endocrinology · 2013Article
- Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
methodsFreshly ejaculated semen was collected from forty-eight normozoospermic human donors. We analyzed the expression of substance P, neurokinin A, neurokinin B, hemokinin-1, NEP and NEP2 in sperm cells by reverse-transcriptase polymerase chain reaction (RT-PCR), western blot and immunocytochemistry assays and evaluated the effects of the neprilysin and neprilysin-2 inhibitor phosphoramidon on sperm motility in the absence and presence of tachykinin receptor-selective antagonists. Sperm motility was measured using WHO procedures or computer-assisted sperm analysis (CASA).
resultsThe mRNAs of the genes that encode substance P/neurokinin A (TAC1), neurokinin B (TAC3), hemokinin-1 (TAC4), neprilysin (MME) and neprilysin-2 (MMEL1) were expressed in human sperm. Immunocytochemistry studies revealed that tachykinin and neprilysin proteins were present in spermatozoa and show specific and differential distributions. Phosphoramidon increased sperm progressive motility and its effects were reduced in the presence of the tachykinin receptor antagonists SR140333 (NK1 receptor-selective) and SR48968 (NK2 receptor-selective) but unmodified in the presence of SR142801 (NK3 receptor-selective).
conclusionThese data show that tachykinins are present in human spermatozoa and participate in the regulation of sperm motility. Tachykinin activity is regulated, at least in part, by neprilysins.
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