ArticleVirology journal2010
Molecular epidemiology of Hepatitis C virus genotypes in Khyber Pakhtoonkhaw of Pakistan.
Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hepatitis C virus prevalence and genotype distribution in Pakistan: Comprehensive review of recent data.World journal of gastroenterology · 2016Pooled it
- Hepatitis C virus genotypes in Pakistan: a systemic review.Virology journal · 2011Pooled it
- Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis.Infectious medicine · 2023Article
- Circulating microRNA-122 in HCV cirrhotic patients with high frequency of genotype 3.PloS one · 2022Article
- Molecular characterization and clinical epidemiology of HCV in District Dir (Lower), Pakistan.Virusdisease · 2018Article
- Molecular characterization of Hepatitis C virus 3a in Peshawar.BMC infectious diseases · 2016Article
- Prevalence of Hepatitis C Virus Genotypes Among Patients in Countries of the Eastern Mediterranean Regional Office of WHO (EMRO): A Systematic Review and Meta-Analysis.Hepatitis monthly · 2016Review
- Prevalence of Blood-Borne Viruses in Health Care Workers of a Northern District in Pakistan: Risk Factors and Preventive Behaviors.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Article
- Diagnostically untypable hepatitis C virus variants: it is time to resolve the problem.World journal of gastroenterology · 2014Article
- Emergence of genetically variant Hepatitis C virus population in response to increased antiviral drug pressure, Pakistan.Virus genes · 2014Article
- Article
- A 3D structural model and dynamics of hepatitis C virus NS3/4A protease (genotype 4a, strain ED43) suggest conformational instability of the catalytic triad: implications in catalysis and drug resistivity.Journal of biomolecular structure & dynamics · 2014Article
- Prevalence of hepatitis C virus genotypes in district bannu, khyber pakhtunkhwa, pakistan.Hepatitis research and treatment · 2014Article
- Prevalence of HCV genotypes in district Mardan.Virology journal · 2013Article
- Determination of HCV genotypes and viral loads in chronic HCV infected patients of Hazara Pakistan.Virology journal · 2011Article
- Expression of core antigen of HCV genotype 3a and its evaluation as screening agent for HCV infection in Pakistan.Virology journal · 2011Article
- Detection of hepatitis C virus and antibodies in postmortem blood and bloodstains.Journal of clinical microbiology · 2011Article
- Promiscuous prediction and conservancy analysis of CTL binding epitopes of HCV 3a viral proteome from Punjab Pakistan: an in silico approach.Virology journal · 2011Article
- Hepatitis C virus genotypes circulating in district Swat of Khyber Pakhtoonkhaw, Pakistan.Virology journal · 2011Article
- Prevalence of active hepatitis c virus infection in district Mansehra Pakistan.Virology journal · 2010Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Six major Hepatitis C virus (HCV) genotypes and hundreds of subtypes have been identified globally. All these genotypes are generally studied for epidemiology, their vaccine development and clinical management. This article comments the frequency distribution of various HCV genotypes circulate in different areas/districts of Khyber Pakhtoonkhaw Province of Pakistan. Sum of 415 HCV RNA PCR positive sera samples were tested by a molecular genotyping assay. Data analysis revealed that out of these 415 HCV RNA positive patients 243 were males and 172 were females. Distribution breakup of the patients was 135, 58, 51, 51, 36, 32, 6, 7 and 9 patients come from the districts of Abbottabad, Mardan, Pehawar, Swat, Haripure, Swabi and Dera Ismail Khan, respectively. Out of the tested samples, genotype specific PCR fragments were observed in 299 (74.82%) patient serum samples. The distribution of genotypes of the typeable samples was as follows: 3 patients (0.72%) each were infected with genotype 1a and genotype 1b; 240 patients (80.26%) of genotype 3a; 25 patients (6.00%) genotype 3b; and 28 patients (6.73%) were observed as with mixed genotypic infection. Sums of 116 serum samples (27.88%) were still found untypeable by the used molecular genotyping system. In conclusion, HCV genotypes 1a, 1b, 3a and 3b are distributed in various parts of KPK among which the genotype 3a is the most frequent genotype.
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