ArticleThe journal of physical chemistry. A2011
Adhesion through single peptide aptamers.
Article in The journal of physical chemistry. A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Organophosphorus Flame Retardants and Metabolic Disruption: AnEnvironmental health perspectives · 2024Article
- The activated ClpP peptidase forcefully grips a protein substrate.Biophysical journal · 2022Article
- Single Molecule Force Spectroscopy Reveals Distinctions in Key Biophysical Parameters of αβ T-Cell Receptors Compared with Chimeric Antigen Receptors Directed at the Same Ligand.The journal of physical chemistry letters · 2021Article
- Modular assembly of proteins on nanoparticles.Nature communications · 2018Article
- Single molecule and multiple bond characterization of catch bond associated cytoadhesion in malaria.Scientific reports · 2017Article
- Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells.Investigational new drugs · 2016Article
- Mechanochemical basis of protein degradation by a double-ring AAA+ machine.Nature structural & molecular biology · 2014Article
- Rapid internal contraction boosts DNA friction.Nature communications · 2013Article
- Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine.Cell · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Aptamer and antibody mediated adhesion is central to biological function and is valuable in the engineering of "lab on a chip" devices. Single molecule force spectroscopy using optical tweezers enables direct nonequilibrium measurement of these noncovalent interactions for three peptide aptamers selected for glass, polystyrene, and carbon nanotubes. A comprehensive examination of the strong attachment between antifluorescein 4-4-20 and fluorescein was also carried out using the same assay. Bond lifetime, barrier width, and free energy of activation are extracted from unbinding histogram data using three single molecule pulling models. The evaluated aptamers appear to adhere stronger than the fluorescein antibody under no- and low-load conditions, yet weaker than antibodies at loads above ∼25 pN. Comparison to force spectroscopy data of other biological linkages shows the diversity of load dependent binding and provides insight into linkages used in biological processes and those designed for engineered systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.