ArticleCell regulation1990
A protein kinase C isozyme is translocated to cytoskeletal elements on activation.
Article in Cell regulation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 258 citations in OpenAlex.
- Antimicrobial agent triclosan suppresses mast cell signaling via phospholipase D inhibition.Journal of applied toxicology : JAT · 2019Article
- Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice.Cell reports · 2018Article
- PKCα diffusion and translocation are independent of an intact cytoskeleton.Scientific reports · 2017Article
- Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac.British journal of pharmacology · 2017Article
- In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation.Inflammation · 2015Article
- Protein kinase C mediates enterohemorrhagic Escherichia coli O157:H7-induced attaching and effacing lesions.Infection and immunity · 2014Article
- Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms.PloS one · 2014Article
- The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.International journal of molecular sciences · 2013Article
- Protein kinase C, an elusive therapeutic target?Nature reviews. Drug discovery · 2012Review
- Receptor for activated C kinase ortholog of second-generation merozoite in Eimeria tenella: clone, characterization, and diclazuril-induced mRNA expression.Parasitology research · 2012Article
- Crosstalk between adenosine A1 and β1-adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes.Journal of cellular physiology · 2012Article
- Rationally designed peptide regulators of protein kinase C.Trends in endocrinology and metabolism: TEM · 2009Review
- Walleye dermal sarcoma virus Orf B functions through receptor for activated C kinase (RACK1) and protein kinase C.Virology · 2008Article
- Developmental expression of the alpha-skeletal actin gene.BMC evolutionary biology · 2008Article
- Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway.Molecular and cellular biology · 2007Article
- PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.Biochemistry · 2007Article
- Happy birthday protein kinase C: past, present and future of a superfamily.Pharmacological research · 2007Article
- Protein kinase C involvement in deoxycholate-induced apoptosis in human gastric cells.Digestive diseases and sciences · 2006Article
- Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Alpha2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Protein kinase C (PKC)1 isozymes comprise a family of related cytosolic kinases that translocate to the cell particulate fraction on stimulation. The activated enzyme is thought to be on the plasma membrane. However, phosphorylation of protein substrates occurs throughout the cell and is inconsistent with plasma membrane localization. Using an isozyme-specific monoclonal antibody we found that, on activation, this PKC isozyme translocates to myofibrils in cardiac myocytes and to microfilaments in fibroblasts. Translocation of this activated PKC isozyme to cytoskeletal elements may explain some of the effects of PKC on cell contractility and morphology. In addition, differences in the translocation site of individual isozymes--and, therefore, phosphorylation of different substrates localized at these sites--may explain the diverse biological effects of PKC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.