ArticleThe ISME journal2011
Unveiling an abundant core microbiota in the human adult colon by a phylogroup-independent searching approach.
Article in The ISME journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- The human gut pan-microbiome presents a compositional core formed by discrete phylogenetic units.Scientific reports · 2018Pooled it
- Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms.PloS one · 2011Trial
- Sexual Dimorphism in Lipid Metabolism and Gut Microbiota in Mice Fed a High-Fat Diet.Nutrients · 2023Article
- The associations between intestinal bacteria of Eospalax cansus and soil bacteria of its habitat.BMC veterinary research · 2022Article
- The species-level microbiota of healthy eyes revealed by the integration of metataxonomics with culturomics and genome analysis.Frontiers in microbiology · 2022Article
- Cupriavidus in the intestinal microbiota of Tibet endemic fish Glyptosternum maculatum can help it adapt to habitat of the Qinghai Tibet Plateau.BMC veterinary research · 2021Article
- Functional differentiation related to decomposing complex carbohydrates of intestinal microbes between two wild zokor species based on 16SrRNA sequences.BMC veterinary research · 2021Article
- A Multiomic Approach to Investigate the Effects of a Weight Loss Program on the Intestinal Health of Overweight Horses.Frontiers in veterinary science · 2021Article
- Contribution of Gut Microbiota to Immunological Changes in Alzheimer's Disease.Frontiers in immunology · 2021Review
- Acute Radiation Syndrome and the Microbiome: Impact and Review.Frontiers in pharmacology · 2021Review
- Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease.Nature communications · 2020Article
- Microbiota Features Associated With a High-Fat/Low-Fiber Diet in Healthy Adults.Frontiers in nutrition · 2020Article
- Article
- Article
- Core Gut Bacteria Analysis of Healthy Mice.Frontiers in microbiology · 2019Article
- Disease outbreak accompanies the dispersive structure of shrimp gut bacterial community with a simple core microbiota.AMB Express · 2018Article
- Changes in the Total Fecal Bacterial Population in Individual Horses Maintained on a Restricted Diet Over 6 Weeks.Frontiers in microbiology · 2017Article
- Diet-Dependent Modular Dynamic Interactions of the Equine Cecal Microbiota.Microbes and environments · 2016Article
- The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions.Therapeutic advances in gastroenterology · 2016Review
- Effect of Dietary Oxalate on the Gut Microbiota of the Mammalian Herbivore Neotoma albigula.Applied and environmental microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential presence of widespread and stable bacterial core phylogroups in the human colon has promoted considerable attention. Despite major efforts, no such phylogroups have yet been identified. Therefore, using a novel phylogroup- and tree-independent approach, we present a reanalysis of 1,114,722 V2 region and 71,550 near full-length 16S rRNA sequences from a total of 210 human beings, with widespread geographic origin, ethnic background and diet, in addition to a wide range of other mammals. We found two highly prevalent core phylogroups (cores 1 and 2), belonging to the clostridial family Lachnospiraceae. These core phylogroups showed a log-normal distribution among human individuals, while non-core phylogroups showed more skewed distributions towards individuals with low levels compared with the log-normal distribution. Molecular clock analyses suggest that core 2 co-evolved with the radiation of vertebrates, while core 1 co-evolved with the mammals. Taken together, the stability, prevalence and potential functionality support the fact that the identified core phylogroups are pivotal in maintaining gut homeostasis and health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.