ArticleMolecular systems biology2010
A model of yeast cell-cycle regulation based on multisite phosphorylation.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- A minimal model for the role of Rim4 in regulating meiotic exit in budding yeast.Molecular biology of the cell · 2026Article
- Modeling the START transition in the budding yeast cell cycle.PLoS computational biology · 2024Article
- Design patterns for the construction of computational biological models.Briefings in bioinformatics · 2024Article
- Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle.iScience · 2020Article
- A hybrid stochastic model of the budding yeast cell cycle.NPJ systems biology and applications · 2020Article
- Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective.Comprehensive Physiology · 2019Review
- A stochastic model of size control in the budding yeast cell cycle.BMC bioinformatics · 2019Article
- Illumination of cell cycle progression by multi-fluorescent sensing system.Cell cycle (Georgetown, Tex.) · 2019Article
- Article
- Cell cycle time series gene expression data encoded as cyclic attractors in Hopfield systems.PLoS computational biology · 2017Article
- Exit from quiescence displays a memory of cell growth and division.Nature communications · 2017Article
- Quantitative characterization of the auxin-inducible degron: a guide for dynamic protein depletion in single yeast cells.Scientific reports · 2017Article
- A Stochastic Model of the Yeast Cell Cycle Reveals Roles for Feedback Regulation in Limiting Cellular Variability.PLoS computational biology · 2016Article
- Asynchronous τ-leaping.The Journal of chemical physics · 2016Article
- Model-Based Analysis of Cell Cycle Responses to Dynamically Changing Environments.PLoS computational biology · 2016Article
- A Model of Yeast Cell-Cycle Regulation Based on a Standard Component Modeling Strategy for Protein Regulatory Networks.PloS one · 2016Article
- Mean field analysis of a spatial stochastic model of a gene regulatory network.Journal of mathematical biology · 2015Article
- Robustness of cell cycle control and flexible orders of signaling events.Scientific reports · 2015Article
- Bistability, oscillations, and traveling waves in frog egg extracts.Bulletin of mathematical biology · 2015Article
- Cell cycle control by a minimal Cdk network.PLoS computational biology · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In order for the cell's genome to be passed intact from one generation to the next, the events of the cell cycle (DNA replication, mitosis, cell division) must be executed in the correct order, despite the considerable molecular noise inherent in any protein-based regulatory system residing in the small confines of a eukaryotic cell. To assess the effects of molecular fluctuations on cell-cycle progression in budding yeast cells, we have constructed a new model of the regulation of Cln- and Clb-dependent kinases, based on multisite phosphorylation of their target proteins and on positive and negative feedback loops involving the kinases themselves. To account for the significant role of noise in the transcription and translation steps of gene expression, the model includes mRNAs as well as proteins. The model equations are simulated deterministically and stochastically to reveal the bistable switching behavior on which proper cell-cycle progression depends and to show that this behavior is robust to the level of molecular noise expected in yeast-sized cells (approximately 50 fL volume). The model gives a quantitatively accurate account of the variability observed in the G1-S transition in budding yeast, which is governed by an underlying sizer+timer control system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.