Trial reportAnnals of surgery2010
Glucose control in severely thermally injured pediatric patients: what glucose range should be the target?
Trial report in Annals of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial.Annals of surgery · 2016Trial
- Impact of stress-induced diabetes on outcomes in severely burned children.Journal of the American College of Surgeons · 2014Trial
- Moderate glucose control results in less negative nitrogen balances in medical intensive care unit patients: a randomized, controlled study.Critical care (London, England) · 2012Trial
- Endocrine disruptions in thermal injuries: exploring immune system interactions.Physiological reviews · 2026Review
- Beyond diabetes: harnessing the power of metformin in burn care.Critical care (London, England) · 2025Review
- Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study.npj aging · 2025Article
- Salivary Proteome Is Altered in Children With Small Area Thermal Burns.Proteomics. Clinical applications · 2025Article
- Identification of novel phenotypes in pediatric sepsis based on blood glucose trajectories.Frontiers in pediatrics · 2025Article
- Metformin is associated with reduced risk of mortality and morbidity in burn patients compared to insulin.Burns : journal of the International Society for Burn Injuries · 2024Article
- Cardiometabolic disease risk markers are increased following burn injury in children.Frontiers in public health · 2023Article
- Expert consensus on the glycemic management of critically ill patients.Journal of intensive medicine · 2022Article
- Chronic Critical Illness and PICS Nutritional Strategies.Journal of clinical medicine · 2021Review
- Evaluation of the use of sitagliptin for insulin resistance in burn patients.International journal of burns and trauma · 2020Article
- Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.International journal of molecular sciences · 2019Review
- Non-Diabetic Hyperglycemia in the Pediatric Age: Why, How, and When to Treat?Current diabetes reports · 2018Review
- Burn injury outcomes in patients with pre-existing diabetic mellitus: Risk of hospital-acquired infections and inpatient mortality.Burns : journal of the International Society for Burn Injuries · 2018Article
- Chronic Critical Illness: Application of What We Know.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2018Review
- A Pediatric Intensive Care Unit Bedside Computer Clinical Decision Support Protocol for Hyperglycemia Is Feasible, Safe and Offers Advantages.Diabetes technology & therapeutics · 2017Article
- Statistical and clinical analysis of alterations in glucose values after burns.Annals of burns and fire disasters · 2016Article
- Anabolic and anticatabolic agents in critical care.Current opinion in critical care · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine which glucose levels are associated with improved morbidity and mortality in thermally injured patients. SUMMARY BACKGROUND DATA: Tight euglycemic control was rapidly implemented in intensive care units around the world, but there is increasing evidence that tight euglycemic control is associated with detrimental outcomes. Currently, no study exists that indicates which glucose range should be targeted.
methodsTwo-hundred and eight severely burned pediatric patients with burns over 30% of their total body surface area were included in this trial. Several statistical models were used to determine the daily average and 6 AM glucose target that were associated with improved morbidity and mortality. Patients were then divided into good glucose controlled and poor glucose controlled patients and demographics, clinical outcomes, infection, sepsis, inflammatory, and hypermetabolic responses were determined.
resultsStatistical modeling showed that hyperglycemia is a strong predictor of adverse hospital outcome and that daily 6 am glucose level of 130 mg/dL and daily average glucose levels of 140 mg/dL are associated with improved morbidity and mortality postburn. When patients were divided into good glucose control and poor glucose control, we found that patients with glucose levels of 130 mg/dL exert attenuated hypermetabolic and inflammatory responses, as well as significantly lower incidence of infections, sepsis, and mortality compared with patients with poor glucose control, P < 0.05.
conclusionsGiven the controversy over glucose range, glucose target, and risks and detrimental outcomes associated with hypoglycemia we suggest that in severely burned patient's blood glucose of 130 mg/dL should be targeted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.