ArticleAnnals of surgery2010
A statewide assessment of surgical site infection following colectomy: the role of oral antibiotics.
Article in Annals of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of baseline risk factors for the development of postoperative ileus in patients undergoing gastrointestinal surgery.Annals of the Royal College of Surgeons of England · 2020Pooled it
- Incidence and Outcomes Associated With Clostridium difficile Infections: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- The Role of Oral Antibiotic Preparation in Elective Colorectal Surgery: A Meta-analysis.Annals of surgery · 2019Pooled it
- The role of oral antibiotics prophylaxis in prevention of surgical site infection in colorectal surgery.International journal of colorectal disease · 2017Pooled it
- Antimicrobial prophylaxis for colorectal surgery.The Cochrane database of systematic reviews · 2014Pooled it
- Combination of oral non-absorbable and intravenous antibiotics versus intravenous antibiotics alone in the prevention of surgical site infections after colorectal surgery: a meta-analysis of randomized controlled trials.Techniques in coloproctology · 2011Pooled it
- Microbial sealants do not decrease surgical site infection for clean-contaminated colorectal procedures.Techniques in coloproctology · 2015Trial
- Ring drape do not protect against surgical site infections in colorectal surgery: a randomised controlled study.International journal of colorectal disease · 2012Trial
- How to prevent postoperative ileus in colorectal surgery? a systematic review.Annals of medicine and surgery (2012) · 2023Review
- Impact of bowel preparation on elective colectomies for diverticulitis: analysis of the NSQIP database.BMC gastroenterology · 2022Article
- Oral Antibiotic Prophylaxis Lowers Surgical Site Infection in Elective Colorectal Surgery: Results of a Pragmatic Cohort Study in Catalonia.Journal of clinical medicine · 2021Article
- Impact of lockdown for SARS-CoV-2 (COVID-19) on surgical site infection rates: a monocentric observational cohort study.Updates in surgery · 2020Observational
- Association of Medicaid Eligibility With Surgical Readmission Among Medicare Beneficiaries.JAMA network open · 2020Article
- The prevalence and root causes of surgical site infections in public versus private hospitals in Ethiopia: a retrospective observational cohort study.Patient safety in surgery · 2019Article
- Statewide Clinic Registries: The Michigan Surgical Quality Collaborative.Clinics in colon and rectal surgery · 2019Review
- Effect of Inclusion of Oral Antibiotics with Mechanical Bowel Preparation on the Risk of Clostridium Difficile Infection After Colectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Invited comment on R. L. Nelson et al. "Topical antimicrobial prophylaxis in colorectal surgery for the prevention of surgical wound infection: a systematic review and meta-analysis".Techniques in coloproctology · 2018Article
- Article
- Review
- Surgical Management of Diverticular Disease in the Elective Setting.Clinics in colon and rectal surgery · 2018Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo determine the utility of adding oral nonabsorbable antibiotics to the bowel prep prior to elective colon surgery. SUMMARY BACKGROUND DATA: Bowel preparation prior to colectomy remains controversial. We hypothesized that mechanical bowel preparation with oral antibiotics (compared with without) was associated with lower rates of surgical site infection (SSI).
methodsTwenty-four Michigan hospitals participated in the Michigan Surgical Quality Collaborative-Colectomy Best Practices Project. Standard perioperative data, bowel preparation process measures, and Clostridium difficile colitis outcomes were prospectively collected. Among patients receiving mechanical bowel preparation, a logistic regression model generated a propensity score that allowed us to match cases differing only in whether or not they had received oral antibiotics.
resultsOverall, 2011 elective colectomies were performed over 16 months. Mechanical bowel prep without oral antibiotics was administered to 49.6% of patients, whereas 36.4% received a mechanical prep and oral antibiotics. Propensity analysis created 370 paired cases (differing only in receiving oral antibiotics). Patients receiving oral antibiotics were less likely to have any SSI (4.5% vs. 11.8%, P = 0.0001), to have an organ space infection (1.8% vs. 4.2%, P = 0.044) and to have a superficial SSI (2.6% vs. 7.6%, P = 0.001). Patients receiving bowel prep with oral antibiotics were also less likely to have a prolonged ileus (3.9% vs. 8.6%, P = 0.011) and had similar rates of C. difficile colitis (1.3% vs. 1.8%, P = 0.58).
conclusionsMost patients in Michigan receive mechanical bowel preparation prior to elective colectomy. Oral antibiotics may reduce the incidence of SSI.
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