ArticleThe Journal of clinical investigation2010
Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold.
Article in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
116 citing papers in PubMed.
- Decoupling Abundance from Centrality: Sexual Dimorphism and Geographical Structuring in thePathogens (Basel, Switzerland) · 2026Article
- Beyond Dominant Symbionts: Low-Abundance Taxa Govern Microbial Network Topology in Sympatric Ticks.Microbial ecology · 2026Article
- Adaptive restructuring of the microbiota promotes overwintering survival of the tick Dermacentor silvarum.Parasites & vectors · 2026Article
- Environmental Low Temperatures Dynamically Reshape the Microbial Diversity and Community Structure of the Vector Tick Haemaphysalis longicornis.Archives of insect biochemistry and physiology · 2026Article
- Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission.The EMBO journal · 2026Article
- Advances in the use of entomopathogenic fungi to control ixodid ticks.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Review
- Host-Specificity and Network Structure of Tick Microbiota in Co-Distributed Species From the Iberian Peninsula.Ecology and evolution · 2025Article
- Arthropod autophagy molecules facilitate Anaplasma phagocytophilum infection of Ixodes scapularis tick cells.Communications biology · 2025Article
- Article
- Aquaporins modulate the cold response of Haemaphysalis longicornis via changes in gene and protein expression of fatty acids.Parasites & vectors · 2025Article
- Genomic and Proteomic Analyses of Bacterial Communities ofMicroorganisms · 2025Article
- Comparative ecological analysis and predictive modeling of tick-borne pathogens.Journal of medical entomology · 2025Article
- A review of acaricides and their resistance mechanisms in hard ticks and control alternatives with synergistic agents.Acta tropica · 2025Review
- Alarming implications: severe fever with thrombocytopenia syndrome and its biological vectors in the context of climate change.Frontiers in microbiology · 2025Review
- The replication rate ofmicroPublication biology · 2025Article
- Impact of climate change on the tick-host-pathogen complex: distribution patterns, disease incidence, and host infestation.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025Review
- Molecular Detection ofAnimals : an open access journal from MDPI · 2024Article
- The Potential Implications of Sex-Specific Differences in the Intestinal Bacteria of the Overwintering Wolf SpiderInsects · 2024Article
- Analysis ofbioRxiv : the preprint server for biology · 2024Article
- Symbiotic bacteria and fungi proliferate in diapause and may enhance overwintering survival in a solitary bee.The ISME journal · 2024Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
In the United States, Ixodes scapularis ticks overwinter in the Northeast and Upper Midwest and transmit the agent of human granulocytic anaplasmosis, Anaplasma phagocytophilum, among other pathogens. We now show that the presence of A. phagocytophilum in I. scapularis ticks increases their ability to survive in the cold. We identified an I. scapularis antifreeze glycoprotein, designated IAFGP, and demonstrated via RNAi knockdown studies the importance of IAFGP for the survival of I. scapularis ticks in a cold environment. Transfection studies also show that IAFGP increased the viability of yeast cells subjected to cold temperature. Remarkably, A. phagocytophilum induced the expression of iafgp, thereby increasing the cold tolerance and survival of I. scapularis. These data define a molecular basis for symbiosis between a human pathogenic bacterium and its arthropod vector and delineate what we believe to be a new pathway that may be targeted to alter the life cycle of this microbe and its invertebrate host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.