ArticleThe Journal of clinical investigation2010
Fitness and freezing: vector biology and human health.
Article in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Molecular Detection of Spotted Fever Group Rickettsiae (Rickettsiales: Rickettsiaceae) in Dermacentor variabilis (Acari: Ixodidae) Collected Along the Platte River in South Central Nebraska.Journal of medical entomology · 2020Article
- Comparative vertical transmission of Rickettsia by Dermacentor variabilis and Amblyomma maculatum.Ticks and tick-borne diseases · 2017Article
- Identification of host proteins involved in rickettsial invasion of tick cells.Infection and immunity · 2015Article
- Amblyomma maculatum Feeding Augments Rickettsia parkeri Infection in a Rhesus Macaque Model: A Pilot Study.PloS one · 2015Article
- Genetic Diversity of Tick-Borne Rickettsial Pathogens; Insights Gained from Distant Strains.Pathogens (Basel, Switzerland) · 2014Article
- Gene expression of tissue-specific molecules in ex vivo Dermacentor variabilis (Acari: Ixodidae) during rickettsial exposure.Journal of medical entomology · 2013Article
- Rickettsia parkeri infection in domestic dogs, Southern Louisiana, USA, 2011.Emerging infectious diseases · 2012Article
- Susceptibility of inbred mice to Rickettsia parkeri.Infection and immunity · 2012Article
- Molecular characterization and tissue-specific gene expression of Dermacentor variabilis α-catenin in response to rickettsial infection.Insect molecular biology · 2012Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Microbes transmitted to mammals by arthropods contend with many factors that could impede survival. To survive, host fitness with infection must outweigh costs. In this issue of the JCI, Neelakanta et al. demonstrate that ticks infected with Anaplasma phagocytophilum show enhanced fitness against freezing injury owing to induced expression of tick "antifreeze glycoprotein." This allows A. phagocytophilum to successfully propagate and survive to cause disease in nonnatural hosts, such as humans. How an intracellular microbe with a small genome subverts host cell function for survival provides insight into the control of some cellular function programs and underscores how vector biology can have an impact on human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.