ArticlePlant physiology2010
SHORT-ROOT and SCARECROW regulate leaf growth in Arabidopsis by stimulating S-phase progression of the cell cycle.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- A multiscale growth atlas of Arabidopsis: linking cell dynamics to organ development.The New phytologist · 2026Pooled it
- Strigolactones Regulate Sugar Allocation to Control Rice Tillering and Root Development via the OsSPL14-OsSHR1-OsSWEET16 Pathway.Plant biotechnology journal · 2026Article
- Tissue-Specific Expression Analysis and Functional Validation ofPlants (Basel, Switzerland) · 2025Article
- The Root Development Genes (RDGs) Network inPlants (Basel, Switzerland) · 2025Article
- Programmable RNA NPlant biotechnology journal · 2024Article
- PpSCARECROW1 (PpSCR1) regulates leaf blade and mid-vein development in Physcomitrium patens.Plant molecular biology · 2024Article
- Genome-wide identification and characterization of3 Biotech · 2023Article
- Article
- Mutations in NAKED-ENDOSPERM IDD genes reveal functional interactions with SCARECROW during leaf patterning in C4 grasses.PLoS genetics · 2023Article
- GRAS transcription factors regulate cell division planes in moss overriding the default rule.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin.The New phytologist · 2022Review
- SHORT-ROOT Controls Cell Elongation in the Etiolated Arabidopsis Hypocotyl.Molecules and cells · 2022Article
- SCARECROW is deployed in distinct contexts during rice and maize leaf development.Development (Cambridge, England) · 2022Article
- (Don't) Look Up!: IsFrontiers in plant science · 2022Article
- Leaf Size Development Differences and Comparative Trancriptome Analyses of Two Poplar Genotypes.Genes · 2021Article
- Tomato transcriptomic response to Tuta absoluta infestation.BMC plant biology · 2021Article
- Single-cell resolution of lineage trajectories in the Arabidopsis stomatal lineage and developing leaf.Developmental cell · 2021Article
- Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress.The Plant cell · 2020Article
- Article
- The Arabidopsis Hypoxia InducibleNon-coding RNA · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
SHORT-ROOT (SHR) and SCARECROW (SCR) are required for stem cell maintenance in the Arabidopsis (Arabidopsis thaliana) root meristem, ensuring its indeterminate growth. Mutation of SHR and SCR genes results in disorganization of the quiescent center and loss of stem cell activity, resulting in the cessation of root growth. This paper reports on the role of SHR and SCR in the development of leaves, which, in contrast to the root, have a determinate growth pattern and lack a persistent stem cell niche. Our results demonstrate that inhibition of leaf growth in shr and scr mutants is not a secondary effect of the compromised root development but is caused by an effect on cell division in the leaves: a reduced cell division rate and early exit of the proliferation phase. Consistent with the observed cell division phenotype, the expression of SHR and SCR genes in leaves is closely associated with cell division activity in most cell types. The increased cell cycle duration is due to a prolonged S-phase duration, which is mediated by up-regulation of cell cycle inhibitors known to restrain the activity of the transcription factor, E2Fa. Therefore, we conclude that, in contrast to their specific roles in cortex/endodermis differentiation and stem cell maintenance in the root, SHR and SCR primarily function as general regulators of cell proliferation in leaves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.