ArticleJournal of neurophysiology2010
Auditory nerve fibers excite targets through synapses that vary in convergence, strength, and short-term plasticity.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 121 citations in OpenAlex.
- Computational Model for Synthesizing Auditory Brainstem Responses to Assess Neuronal Alterations in Aging and Autistic Animal Models.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells.Cell research · 2026Article
- Optogenetic circuit mapping reveals connectivity and synaptic physiology of T-stellate projections from the cochlear nucleus to the auditory midbrain.bioRxiv : the preprint server for biology · 2026Article
- Celf4 Regulates Excitability of Bushy Cells in the Cochlear Nucleus of the Mouse Brainstem.Cellular and molecular neurobiology · 2026Article
- Effects of Gap Junctions and Inhibition on the Synchronization Behavior of a Biophysically Detailed Neural Network Model of Bushy Cells.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Channelrhodopsin variants for high-rate optogenetic neurostimulation at low light intensities.EMBO molecular medicine · 2026Article
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- An anatomical and physiological basis for flexible coincidence detection in the auditory system.eLife · 2025Article
- Convergence of Type 1 Spiral Ganglion Neuron Subtypes onto Principal Neurons of the Anteroventral Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Fast Inhibition Slows and Desynchronizes Mouse Auditory Efferent Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse.Frontiers in molecular neuroscience · 2024Article
- Article
- Imaging Voltage Globally and in Isofrequency Lamina in Slices of Mouse Ventral Cochlear Nucleus.eNeuro · 2023Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Expression and Neurotransmitter Association of the Synaptic Calcium Sensor Synaptotagmin in the Avian Auditory Brain Stem.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Mammalian octopus cells are direction selective to frequency sweeps by excitatory synaptic sequence detection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Time Course of Activity-Dependent Changes in Auditory Nerve Synapses Reveals Multiple Underlying Cellular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- RIM-Binding Protein 2 Organizes CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
15 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
Funding
Abstract
Auditory nerve fibers are the major source of excitation to the three groups of principal cells of the ventral cochlear nucleus (VCN), bushy, T stellate, and octopus cells. Shock-evoked excitatory postsynaptic currents (eEPSCs) in slices from mice showed systematic differences between groups of principal cells, indicating that target cells contribute to determining pre- and postsynaptic properties of synapses from spiral ganglion cells. Bushy cells likely to be small spherical bushy cells receive no more than three, most often two, excitatory inputs; those likely to be globular bushy cells receive at least four, most likely five, inputs. T stellate cells receive 6.5 inputs. Octopus cells receive >60 inputs. The N-methyl-d-aspartate (NMDA) components of eEPSCs were largest in T stellate, smaller in bushy, and smallest in octopus cells, and they were larger in neurons from younger than older mice. The average AMPA conductance of a unitary input is 22 ± 15 nS in both groups of bushy cells, <1.5 nS in octopus cells, and 4.6 ± 3 nS in T stellate cells. Sensitivity to philanthotoxin (PhTX) and rectification in the intracellular presence of spermine indicate that AMPA receptors that mediate eEPSCs in T stellate cells contain more GluR2 subunits than those in bushy and octopus cells. The AMPA components of eEPSCs were briefer in bushy (0.5 ms half-width) than in T stellate and octopus cells (0.8-0.9 ms half-width). Widening of eEPSCs in the presence of cyclothiazide (CTZ) indicates that desensitization shortens eEPSCs. CTZ-insensitive synaptic depression of the AMPA components was greater in bushy and octopus than in T stellate cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.