ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Hippocampal ripple-contingent training accelerates trace eyeblink conditioning and retards extinction in rabbits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Imagination as a fundamental function of the hippocampus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice.Neuroscience bulletin · 2021Article
- Dark control: The default mode network as a reinforcement learning agent.Human brain mapping · 2020Article
- The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation.Nature reviews. Neuroscience · 2018Review
- Real-time classification of experience-related ensemble spiking patterns for closed-loop applications.eLife · 2018Article
- Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task.eLife · 2016Article
- Age Is Associated with Reduced Sharp-Wave Ripple Frequency and Altered Patterns of Neuronal Variability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Hippocampal Non-Theta-Contingent Eyeblink Classical Conditioning: A Model System for Neurobiological Dysfunction.Frontiers in psychiatry · 2016Review
- Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning.Hippocampus · 2015Review
- Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Effects of hippocampal state-contingent trial presentation on hippocampus-dependent nonspatial classical conditioning and extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Review
- Project DyAdd: classical eyeblink conditioning in adults with dyslexia and ADHD.Experimental brain research · 2012Article
- Disrupting neural activity related to awake-state sharp wave-ripple complexes prevents hippocampal learning.Frontiers in behavioral neuroscience · 2012Article
- Learning to learn: theta oscillations predict new learning, which enhances related learning and neurogenesis.PloS one · 2012Article
- Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Reactivation, replay, and preplay: how it might all fit together.Neural plasticity · 2011Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are at least two distinct oscillatory states of the hippocampus that are related to distinct behavioral patterns. Theta (4-12 Hz) oscillation has been suggested to indicate selective attention during which the animal concentrates on some features of the environment while suppressing reactivity to others. In contrast, sharp-wave ripples ( approximately 200 Hz) can be seen in a state in which the hippocampus is at its most responsive to any kind of afferent stimulation. In addition, external stimulation tends to evoke and reset theta oscillation, the phase of which has been shown to modulate synaptic plasticity in the hippocampus. Theoretically, training on a hippocampus-dependent learning task contingent upon ripples could enhance learning rate due to elevated responsiveness and enhanced phase locking of the theta oscillation. We used a brain-computer interface to detect hippocampal ripples in rabbits to deliver trace eyeblink conditioning and extinction trials selectively contingent upon them. A yoked control group was trained regardless of their ongoing neural state. Ripple-contingent training expedited acquisition of the conditioned response early in training and evoked stronger theta-band phase locking to the conditioned stimulus. Surprisingly, ripple-contingent training also resulted in slower extinction in well trained animals. We suggest that the ongoing oscillatory activity in the hippocampus determines the extent to which a stimulus can induce a phase reset of the theta oscillation, which in turn is the determining factor of learning rate in trace eyeblink conditioning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.