ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Transcranial electric stimulation entrains cortical neuronal populations in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03062553 (Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation), which is not on this map. Cited by 222 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation
Who cites it
222 citing papers in PubMed.
- Personalized high-intensity temporal interference stimulation decouples cerebellar networks to enhance implicit learning.Journal of neuroengineering and rehabilitation · 2026Trial
- Effect of Transcranial Alternating Current Stimulation on Prevention of Postoperative Pain After Video-Assisted Thoracic Surgery: A Randomized Controlled Trial.Pain research & management · 2026Trial
- TRanscranial AlterNating current stimulation FOR patients with mild Alzheimer's Disease (TRANSFORM-AD): a randomized controlled clinical trial.Alzheimer's research & therapy · 2024Trial
- Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer's disease.Alzheimer's research & therapy · 2021Trial
- A specific phase of transcranial alternating current stimulation at the β frequency boosts repetitive paired-pulse TMS-induced plasticity.Scientific reports · 2021Trial
- Non-invasive electrical brain stimulation for vision restoration after stroke: An exploratory randomized trial (REVIS).Restorative neurology and neuroscience · 2021Trial
- Cerebellar Theta Frequency Transcranial Pulsed Stimulation Increases Frontal Theta Oscillations in Patients with Schizophrenia.Cerebellum (London, England) · 2019Trial
- The effects of transcranial alternating current stimulation (tACS) at individual alpha peak frequency (iAPF) on motor cortex excitability in young and elderly adults.Experimental brain research · 2018Trial
- Using high-amplitude and focused transcranial alternating current stimulation to entrain physiological tremor.Scientific reports · 2018Trial
- Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings.Nature communications · 2017Trial
- State-dependent effects of transcranial oscillatory currents on the motor system: what you think matters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Is transcranial alternating current stimulation effective in modulating brain oscillations?PloS one · 2013Trial
- The Effects of High-Definition Transcranial Alternating Current Stimulation (HD-tACS) on Dual-Task Performance and Upper-Limb Multi-Joint Motor Control.Life (Basel, Switzerland) · 2026Article
- High frequency electrical stimulation paces fast spiking interneurons and modulates cellular information processing.Communications biology · 2026Article
- Hippocampal rhythm modulation via frequency-tuned trigeminal nerve stimulation.Translational psychiatry · 2026Article
- Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Non-vectorial integration of intersectional short-pulse stimulation enables enhanced deep brain modulation and effective seizure control.Communications medicine · 2026Article
- Epicranial electrical stimulation improves non-navigational spatial memory in macaque monkeys.Neuroimage. Reports · 2026Article
- Modulating Phonological Short-Term Memory in Stroke Survivors With Aphasia Using Transcranial Alternating Current Stimulation.Neurorehabilitation and neural repair · 2026Article
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
162 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Low intensity electric fields have been suggested to affect the ongoing neuronal activity in vitro and in human studies. However, the physiological mechanism of how weak electrical fields affect and interact with intact brain activity is not well understood. We performed in vivo extracellular and intracellular recordings from the neocortex and hippocampus of anesthetized rats and extracellular recordings in behaving rats. Electric fields were generated by sinusoid patterns at slow frequency (0.8, 1.25 or 1.7 Hz) via electrodes placed on the surface of the skull or the dura. Transcranial electric stimulation (TES) reliably entrained neurons in widespread cortical areas, including the hippocampus. The percentage of TES phase-locked neurons increased with stimulus intensity and depended on the behavioral state of the animal. TES-induced voltage gradient, as low as 1 mV/mm at the recording sites, was sufficient to phase-bias neuronal spiking. Intracellular recordings showed that both spiking and subthreshold activity were under the combined influence of TES forced fields and network activity. We suggest that TES in chronic preparations may be used for experimental and therapeutic control of brain activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.