ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Developmental mechanisms for suppressing the effects of delayed release at the endbulb of Held.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells.Cell research · 2026Article
- Calcium Sensors of Neurotransmitter Release.Advances in neurobiology · 2023Article
- Upregulated CaCells · 2022Article
- Ultrastructural maturation of the endbulb of Held active zones comparing wild-type and otoferlin-deficient mice.iScience · 2021Article
- Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.Science advances · 2021Article
- Mechanisms and Functional Consequences of Presynaptic Homeostatic Plasticity at Auditory Nerve Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Short-term synaptic depression can increase the rate of information transfer at a release site.PLoS computational biology · 2019Article
- Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset.Frontiers in cellular neuroscience · 2019Article
- Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Synaptic transmission at the endbulb of Held deteriorates during age-related hearing loss.The Journal of physiology · 2017Article
- Low Somatic Sodium Conductance Enhances Action Potential Precision in Time-Coding Auditory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Asynchronous presynaptic glutamate release enhances neuronal excitability during the post-spike refractory period.The Journal of physiology · 2016Article
- Activity-dependent, homeostatic regulation of neurotransmitter release from auditory nerve fibers.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Morphological and physiological development of auditory synapses.Hearing research · 2014Review
- Large somatic synapses on neurons in the ventral lateral lemniscus work in pairs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.Annual review of physiology · 2014Review
- Stochastic properties of neurotransmitter release expand the dynamic range of synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Morphological characterization of bushy cells and their inputs in the laboratory mouse (Mus musculus) anteroventral cochlear nucleus.PloS one · 2013Article
- Short-term plasticity and auditory processing in the ventral cochlear nucleus of normal and hearing-impaired animals.Hearing research · 2011Review
- Factors controlling the input-output relationship of spherical bushy cells in the gerbil cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Delayed release of neurotransmitter, also called asynchronous release, is commonly observed at synapses, yet its influence on transmission of spike information is unknown. We examined this issue at endbulb of Held synapses, which are formed by auditory nerve fibers onto bushy cells in the cochlear nucleus. Endbulbs from CBA/CaJ mice aged P6-P49 showed prominent delayed release when driven at physiologically relevant rates. In bushy cells from mice before the onset of hearing (P6-P12), spikes were driven by delayed release up to 100 ms after presynaptic activity. However, no such spikes were observed in bushy cells from mice after the onset of hearing (>P14). Dynamic-clamp experiments indicated that delayed release can drive spikes in older bushy cells provided synchronous release is absent, suggesting that activity normally suppresses these spikes. Application of apamin or alpha-dendrotoxin revealed late spikes in older bushy cells, suggesting that postsynaptic activation of K(V)1.x and SK channels during spiking suppresses the subsequent effects of delayed release. The developmental upregulation of these potassium channels would be highly adaptive for temporally precise auditory processing. Furthermore, delayed release appeared to influence synchronous neurotransmitter release. Enhancement of delayed release using strontium was correlated with lower firing probability in current clamp and smaller synchronous EPSCs in voltage clamp. EGTA-AM had the opposite effects. These effects were consistent with delayed and synchronous release competing for a single vesicle pool. Thus delayed release apparently has negative presynaptic and postsynaptic consequences at the endbulb, which are partly mitigated by postsynaptic potassium channel expression.
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