ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Dynamics of the Parkinsonian striatal microcircuit: entrainment into a dominant network state.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 86 citations in OpenAlex.
- Pathological cell assembly dynamics in a striatal MSN network model.Frontiers in computational neuroscience · 2024Article
- Striatal ensemble activity in an innate naturalistic behavior.bioRxiv : the preprint server for biology · 2023Article
- Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging.PloS one · 2023Article
- Editorial: Reconfiguration of neuronal ensembles throughout learning.Frontiers in systems neuroscience · 2023Article
- Conceptual framework for neuronal ensemble identification and manipulation related to behavior using calcium imaging.Neurophotonics · 2022Review
- Striatal mechanisms of turning behaviour following unilateral dopamine depletion in mice.The European journal of neuroscience · 2022Article
- Dimensionality reduction and recurrence analysis reveal hidden structures of striatal pathological states.Frontiers in systems neuroscience · 2022Article
- Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism.Frontiers in synaptic neuroscience · 2022Article
- Translational neuronal ensembles: Neuronal microcircuits in psychology, physiology, pharmacology and pathology.Frontiers in systems neuroscience · 2022Review
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- Identification and quantification of neuronal ensembles in optical imaging experiments.Journal of neuroscience methods · 2021Article
- Striatal network modeling in Huntington's Disease.PLoS computational biology · 2020Article
- Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.The European journal of neuroscience · 2019Article
- Primate beta oscillations and rhythmic behaviors.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons.The European journal of neuroscience · 2017Article
- Historical perspective of cell transplantation in Parkinson's disease.World journal of transplantation · 2017Review
- Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information.Neuron · 2016Article
- Temporal correlations among functionally specialized striatal neural ensembles in reward-conditioned mice.Journal of neurophysiology · 2016Article
- Cell Assembly Dynamics of Sparsely-Connected Inhibitory Networks: A Simple Model for the Collective Activity of Striatal Projection Neurons.PLoS computational biology · 2016Article
- Desynchronization of fast-spiking interneurons reduces β-band oscillations and imbalance in firing in the dopamine-depleted striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Neuronal synchronization in basal ganglia circuits plays a key role in the encoding of movement, procedural memory storage and habit formation. Striatal dopamine (DA) depletion during Parkinsonism causes abnormal synchronization in corticobasal ganglia loops resulting in motor dysfunction. However, the dynamics of the striatal microcircuit underlying abnormal synchronization in Parkinsonism is poorly understood. Here we used targeted whole-cell recordings, calcium imaging allowing the recording from dozens of cells simultaneously and analytical approaches, to describe the striking alterations in network dynamics that the striatal microcircuit undergoes following DA depletion in a rat model of Parkinson disease (PD): In addition to a significant enhancement of basal neuronal activity frequent periods of spontaneous synchronization were observed. Multidimensional reduction techniques of vectorized network dynamics revealed that increased synchronization resulted from a dominant network state that absorbed most spontaneously active cells. Abnormal synchronous activity can be virtually abolished by glutamatergic antagonists, while blockade of GABAergic transmission facilitates the engagement of striatal cell assemblies in the dominant state. Finally, a dopaminergic receptor agonist was capable of uncoupling neurons from the dominant state. Abnormal synchronization and "locking" into a dominant state may represent the basic neuronal mechanism that underlies movement disorders at the microcircuit level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.