ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Accumulation of amyloid beta in human glioblastomas.Clinical and experimental immunology · 2020Trial
- The cancer Alzheimer's disease paradox.npj aging · 2026Article
- Oligomer-Aβ42 suppress glioma progression via potentiating phagocytosis of microglia.CNS neuroscience & therapeutics · 2024Article
- Amyloid β-based therapy for Alzheimer's disease: challenges, successes and future.Signal transduction and targeted therapy · 2023Review
- Physiological Roles of Monomeric Amyloid-β and Implications for Alzheimer's Disease Therapeutics.Experimental neurobiology · 2022Review
- Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells.Scientific reports · 2021Article
- Distinguishing Alzheimer's Disease Patients and Biochemical Phenotype Analysis Using a Novel Serum Profiling Platform: Potential Involvement of the VWF/ADAMTS13 Axis.Brain sciences · 2021Article
- Presenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma.Cell communication and signaling : CCS · 2020Article
- Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors.International journal of molecular sciences · 2019Article
- Novel Functions of the Neurodegenerative-Related Gene Tau in Cancer.Frontiers in aging neuroscience · 2019Article
- Article
- Heparan sulfate S-domains and extracellular sulfatases (Sulfs): their possible roles in protein aggregation diseases.Glycoconjugate journal · 2018Review
- The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease.Frontiers in aging neuroscience · 2018Review
- Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation.Neuro-oncology · 2016Article
- Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Perlecan domain V inhibits amyloid-β induced brain endothelial cell toxicity and restores angiogenic function.Journal of Alzheimer's disease : JAD · 2014Article
- Hypoxia induces angiogenic factors in brain microvascular endothelial cells.Microvascular research · 2012Article
- Brain microvasculature and hypoxia-related proteins in Alzheimer's disease.International journal of clinical and experimental pathology · 2011Article
- Lower Plasma Amyloid Beta - 42 Levels Associated With Worse Survival in Patients With Glioma.In vivo (Athens, Greece)Article
- A preliminary study on the effect of quantified cranial osteopathic manipulation on wild-type and transgenic rat models of Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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14 authors.
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Abstract
Alzheimer's disease (AD) is the most common form of dementia among the aging population and is characterized pathologically by the progressive intracerebral accumulation of beta-amyloid (Abeta) peptides and neurofibrillary tangles. The level of proangiogenic growth factors and inflammatory mediators with proangiogenic activity is known to be elevated in AD brains which has led to the supposition that the cerebrovasculature of AD patients is in a proangiogenic state. However, angiogenesis depends on the balance between proangiogenic and antiangiogenic factors and the brains of AD patients also show an accumulation of endostatin and Abeta peptides which have been shown to be antiangiogenic. To determine whether angiogenesis is compromised in the brains of two transgenic mouse models of AD overproducing Abeta peptides (Tg APPsw and Tg PS1/APPsw mice), we assessed the growth and vascularization of orthotopically implanted murine gliomas since they require a high degree of angiogenesis to sustain their growth. Our data reveal that intracranial tumor growth and angiogenesis is significantly reduced in Tg APPsw and Tg PS1/APPsw mice compared with their wild-type littermates. In addition, we show that Abeta inhibits the angiogenesis stimulated by glioma cells when cocultured with human brain microvascular cells on a Matrigel layer. Altogether our data suggest that the brain of transgenic mouse models of AD does not constitute a favorable environment to support neoangiogenesis and may explain why vascular insults synergistically precipitate the cognitive presentation of AD.
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