ArticleJournal of virology2010
Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spread.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Human alphacoronavirus replication and innate immune induction in airway culture systems.mBio · 2026Article
- [A new paradigm for the development of neurodegenerative diseases on the example of Alzheimer's disease and Parkinson's disease.]Advances in gerontology = Uspekhi gerontologii · 2022Article
- SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?Journal of neuroscience research · 2021Review
- Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?Frontiers in cellular neuroscience · 2021Review
- Neuropsychiatric manifestations of COVID-19 and possible pathogenic mechanisms: Insights from other coronaviruses.Asian journal of psychiatry · 2020Review
- Neurobiology of coronaviruses: Potential relevance for COVID-19.Neurobiology of disease · 2020Review
- Article
- Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43.Journal of virology · 2018Article
- Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion.Journal of virology · 2017Article
- Formation of fibroblastic reticular network in the brain after infection with neurovirulent murine coronavirus.Neuropathology : official journal of the Japanese Society of Neuropathology · 2016Article
- Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.Journal of virology · 2016Article
- MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus.Journal of virology · 2015Article
- Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.Journal of virology · 2013Article
- Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice.PloS one · 2013Article
- A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry.Journal of neurovirology · 2012Article
- Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus.Journal of virology · 2011Article
- Viral encephalomyelitis.PLoS pathogens · 2011Article
- Pathogenesis of neurotropic murine coronavirus is multifactorial.Trends in pharmacological sciences · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Coronavirus infection of the murine central nervous system (CNS) provides a model for studies of viral encephalitis and demyelinating disease. Mouse hepatitis virus (MHV) neurotropism varies by strain: MHV-A59 causes mild encephalomyelitis and demyelination, while the highly neurovirulent strain JHM.SD (MHV-4) causes fatal encephalitis with extensive neuronal spread of virus. In addition, while neurons are the predominant CNS cell type infected in vivo, the canonical receptor for MHV, the carcinoembryonic antigen family member CEACAM1a, has been demonstrated only on endothelial cells and microglia. In order to investigate whether CEACAM1a is also expressed in other cell types, ceacam1a mRNA expression was quantified in murine tissues and primary cells. As expected, among CNS cell types, microglia expressed the highest levels of ceacam1a, but lower levels were also detected in oligodendrocytes, astrocytes, and neurons. Given the low levels of neuronal expression of ceacam1a, primary neurons from wild-type and ceacam1a knockout mice were inoculated with MHV to determine the extent to which CEACAM1a-independent infection might contribute to CNS infection. While both A59 and JHM.SD infected small numbers of ceacam1a knockout neurons, only JHM.SD spread efficiently to adjacent cells in the absence of CEACAM1a. Quantification of mRNA for the ceacam1a-related genes ceacam2 and psg16 (bCEA), which encode proposed alternative MHV receptors, revealed low ceacam2 expression in microglia and oligodendrocytes and psg16 expression exclusively in neurons; however, only CEACAM2 mediated infection in human 293T cells. Therefore, neither CEACAM2 nor PSG16 is likely to be an MHV receptor on neurons, and the mechanism for CEACAM1a-independent neuronal spread of JHM.SD remains unknown.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.