Evidence map›Paper›PMID 20739504›Full record

ArticleClinical and vaccine immunology : CVI2010

Serological evidence of human klassevirus infection.

Alexander L Greninger, Lori Holtz, Gagandeep Kang, Donald Ganem, David Wang, Joseph L DeRisi

Abstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Picornavirus--host interactions to construct viral secretory membranes.Progress in molecular biology and translational science · 2015
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander L GreningerDepartments of Molecular Microbiology and Pathology and Immunology, Howard Hughes Medical Institute,Washington University, St. Louis, MO 63110, USA.
Lori Holtz
Gagandeep Kang
Donald Ganem
David Wang
Joseph L DeRisi

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Characterization of a Newly Discovered Picornavirus From a Patient With DiarrheaF32DK083867 · NIDDK · WASHINGTON UNIVERSITY · PI HOLTZ, LORI R · 2009 to 2009
$62k
Howard Hughes Medical InstituteNIDDK NIH HHS F32 DK083867NIDDK NIH HHS F32 DK083867-01NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK 52574NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.

Indexed as

Antigens, ViralAdolescentAdultAgedChildChild, PreschoolEnzyme-Linked Immunosorbent AssayHumansInfantInfant, NewbornMiddle AgedMolecular Sequence DataPicornaviridaePicornaviridae InfectionsReverse Transcriptase Polymerase Chain ReactionRNA, ViralAntigens, ViralRNA, ViralViral Nonstructural Proteins

Identifiers

PMID20739504
PMCPMC2952992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.