ArticleJournal of the Royal Society, Interface2011
Macromolecular dynamics in red blood cells investigated using neutron spectroscopy.
Article in Journal of the Royal Society, Interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Model for small-angle scattering analysis of membranes with protein-like inclusions.Journal of applied crystallography · 2025Article
- Dielectric Responses of Cytosolic Water Change with Aging of Circulating Red Blood Cells.Cells · 2025Article
- Biothermodynamics of Hemoglobin and Red Blood Cells: Analysis of Structure and Evolution of Hemoglobin and Red Blood Cells, Based on Molecular and Empirical Formulas, Biosynthesis Reactions, and Thermodynamic Properties of Formation and Biosynthesis.Journal of molecular evolution · 2024Article
- Effect of red blood cell shape changes on haemoglobin interactions and dynamics: a neutron scattering study.Royal Society open science · 2020Article
- Temperature dependence of nanoscale dynamic processes measured in living millipedes by high resolution inelastic and elastic neutron scattering.Scientific reports · 2019Article
- Use of small-angle X-ray scattering to resolve intracellular structure changes ofJournal of applied crystallography · 2016Article
- Photoactivation Reduces Side-Chain Dynamics of a LOV Photoreceptor.Biophysical journal · 2016Article
- Correlation between supercoiling and conformational motions of the bacterial flagellar filament.Biophysical journal · 2013Article
- Neutron scattering: a tool to detect in vivo thermal stress effects at the molecular dynamics level in micro-organisms.Journal of the Royal Society, Interface · 2013Article
- Dynamics-stability relationships in apo- and holomyoglobin: a combined neutron scattering and molecular dynamics simulations study.Biophysical journal · 2012Article
- Protein self-diffusion in crowded solutions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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4 authors.
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Abstract
We present neutron scattering measurements on the dynamics of haemoglobin (Hb) in human red blood cells (RBCs) in vivo. Global and internal Hb dynamics were measured in the ps to ns time and Å length scales using quasi-elastic neutron backscattering spectroscopy. We observed the cross over from global Hb short-time to long-time self-diffusion. Both short- and long-time diffusion coefficients agree quantitatively with predicted values from the hydrodynamic theory of non-charged hard-sphere suspensions when a bound water fraction of around 0.23 gram H(2)O per gram Hb is taken into account. The higher amount of water in the cells facilitates internal protein fluctuations in the ps time scale when compared with fully hydrated Hb powder. Slower internal dynamics of Hb in RBCs in the ns time range were found to be rather similar to results obtained with fully hydrated protein powders, solutions and Escherichia coli cells.
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