A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

20 citing papers in PubMed.

1. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.PloS one · 2012
   Trial
2. Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.Nature communications · 2022
   Article
3. The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine.Methods in molecular biology (Clifton, N.J.) · 2022
   Article
4. The Roles of the Let-7 Family of MicroRNAs in the Regulation of Cancer Stemness.Cells · 2021
   Review
5. Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma.Oncology letters · 2021
   Article
6. Similarities between the Yin/Yang Doctrine and Hormesis in Toxicology and Pharmacology.Trends in pharmacological sciences · 2020
   Review
7. MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication.Journal of molecular medicine (Berlin, Germany) · 2016
   Article
8. LIN28B is highly expressed in atypical teratoid/rhabdoid tumor (AT/RT) and suppressed through the restoration of SMARCB1.Cancer cell international · 2016
   Article
9. Lin28B over-expression mediates the repression of let-7 by hepatitis B virus X protein in hepatoma cells.International journal of clinical and experimental medicine · 2015
   Article
10. Identification of small molecule inhibitors of Zcchc11 TUTase activity.RNA biology · 2015
    Article
11. PSP94 contributes to chemoresistance and its peptide derivative PCK3145 represses tumor growth in ovarian cancer.Oncogene · 2014
    Article
12. HMGA1 and HMGA2 expression and comparative analyses of HMGA2, Lin28 and let-7 miRNAs in oral squamous cell carcinoma.BMC cancer · 2014
    Article
13. PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.Cell death & disease · 2014
    Article
14. LIN28B promotes colon cancer migration and recurrence.PloS one · 2014
    Article
15. Analysis on cDNA sequence, alternative splicing and polymorphisms associated with timing of puberty of Lin28B gene in goats.Molecular biology reports · 2013
    Article
16. MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.The Journal of clinical investigation · 2013
    Article
17. Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer.PloS one · 2013
    Article
18. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.Cell · 2011
    Article
19. MicroRNAs and Gastroenterological Cancers.Drug discovery today. Disease mechanisms · 2011
    Article
20. Existence of inverted profile in chemically responsive molecular pathways in the zebrafish liver.PloS one · 2011
    Article

Corrections and comments

• Comment on
  Lin28 promotes transformation and is associated with advanced human malignancies.2009

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.